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Pub. No.:    WO/2009/063249    International Application No.:    PCT/GB2008/051069
Publication Date: 22.05.2009 International Filing Date: 17.11.2008
C12Q 1/68 (2006.01)
Applicants: THE SECRETARY OF STATE FOR DEFENCE [GB/GB]; Dstl Porton Down Salisbury Wiltshire SP4 0JQ (GB) (For All Designated States Except US).
BROOKS, Timothy John Gilby [GB/GB]; (GB) (For US Only).
JACKSON, Matthew Christopher [GB/GB]; (GB) (For US Only).
LUKASZEWSKI, Roman Antoni [GB/GB]; (GB) (For US Only).
PEARCE, Martin Julian [GB/GB]; (GB) (For US Only).
TURNER, Carrie Jane [GB/GB]; (GB) (For US Only).
YATES, Amanda Marie [GB/GB]; (GB) (For US Only)
Inventors: BROOKS, Timothy John Gilby; (GB).
JACKSON, Matthew Christopher; (GB).
LUKASZEWSKI, Roman Antoni; (GB).
PEARCE, Martin Julian; (GB).
TURNER, Carrie Jane; (GB).
YATES, Amanda Marie; (GB)
Agent: DIPR Formalities Section; MOD Abbey Wood Poplar 2a #2218 Bristol BS34 8JH (GB)
Priority Data:
0722582.4 16.11.2007 GB
Abstract: front page image
(EN)The invention relates to a method for screening a biological sample to detect early stages of infection, SIRS or sepsis comprising the steps of detecting expression of a first set of informative biomarkers by RT-PCR and detecting expression of a second set of informative bio markers by RT-PCR; analysing the results of detection; classifying said sample according to the likelihood and/or timing of the development of overt infection.
(FR)L'invention porte sur une méthode de criblage d'un échantillon biologique pour y détecter des stades précoces d'infection, de SIRS ou de sepsie, consistant: à détecter l'expression d'un premier jeu de biomarqueurs informateurs par RT-PCR; à détecter l'expression d'un deuxième jeu de biomarqueurs informateurs par RT-PCR; a analyser les résultats des détections; et à classer ledit échantillon selon la probabilité et/ou le temps de développement de l'infection déclarée.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)