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1. (WO2009063235) DERIVATIVES OF 1,9-DIHYDRO-6H-PURIN-6-ONE AND USES THEREOF-018
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/063235    International Application No.:    PCT/GB2008/051045
Publication Date: 22.05.2009 International Filing Date: 11.11.2008
IPC:
C07D 473/06 (2006.01), C07D 473/22 (2006.01), A61K 31/522 (2006.01), A61P 31/04 (2006.01)
Applicants: ASTRAZENECA AB [SE/SE]; S-151 85 Södertälje (SE) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
ASTRAZENECA UK LIMITED [GB/GB]; 15 Stanhope Gate, London Greater London W1K 1LN (GB) (MG only).
BREAULT, Gloria [US/US]; (US) (For US Only).
GENG, Bolin [US/US]; (US) (For US Only)
Inventors: BREAULT, Gloria; (US).
GENG, Bolin; (US)
Agent: ASTRAZENECA INTELLECTUAL PROPERTY; AstraZeneca AB, S-SE-151 85 Södertälje (SE)
Priority Data:
60/987,464 13.11.2007 US
Title (EN) DERIVATIVES OF 1,9-DIHYDRO-6H-PURIN-6-ONE AND USES THEREOF-018
(FR) DÉRIVÉS DE 1,9-DIHYDRO-6H-PURIN-6-ONE ET LEURS UTILISATIONS -018
Abstract: front page image
(EN)The invention relates to chemical compounds, or pharmaceutically acceptable salts thereof of the formula (I): which have bacterial MurI inhibitory activity and are accordingly useful for their treatment and prophylaxis of bacterial infection, e.g., E.faecalis or E. faecium infection. Further, the invention relates to methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of the compounds, to pharmaceutical compositions containing them, and to their use in the manufacture of medicaments of use in the treatment and prevention of various bacterial diseases in a warm-blooded animal such as man.
(FR)L'invention concerne des composés chimiques, ou des sels acceptables de ceux-ci du point de vue pharmaceutique, de la formule (I) : qui ont une activité inhibitrice de MurI bactérien et qui s'utilisent, par conséquent, pour le traitement et la prophylaxie d'une infection bactérienne, par exemple une infection par E. faecalis ou E. faecium. De plus, l'invention concerne des procédés de traitement du corps humain ou animal. L'invention concerne également des procédés de fabrication des composés, des compositions pharmaceutiques les contenant et leur utilisation dans la fabrication de médicaments utiles dans le traitement et la prévention de diverses maladies bactériennes chez un animal à sang chaud tel que l'homme.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)