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1. (WO2009063054) NOVEL BIFUNCTIONAL COMPOUNDS WHICH INHIBIT PROTEIN KINASES AND HISTONE DEACETYLASES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/063054    International Application No.:    PCT/EP2008/065561
Publication Date: 22.05.2009 International Filing Date: 14.11.2008
IPC:
C07D 213/68 (2006.01), C07D 239/94 (2006.01), C07D 401/04 (2006.01), C07D 401/12 (2006.01), C07D 401/14 (2006.01), C07D 403/12 (2006.01), C07D 405/04 (2006.01), C07D 409/04 (2006.01), C07D 409/12 (2006.01), C07D 409/14 (2006.01), C07D 417/04 (2006.01), C07D 417/14 (2006.01), A61K 31/517 (2006.01), A61P 35/00 (2006.01)
Applicants: 4SC AG [DE/DE]; Am Klopferspitz 19a 82152 Planegg-martinsried (DE) (For All Designated States Except US).
BÄR, Thomas [DE/DE]; (DE) (For US Only).
MAIER, Thomas [DE/DE]; (DE) (For US Only).
BECKERS, Thomas [DE/DE]; (DE) (For US Only).
CIOSSEK, Thomas [DE/DE]; (DE) (For US Only).
MAHBOOBI, Siavosh [DE/DE]; (DE) (For US Only).
SELLMER, Andreas [DE/DE]; (DE) (For US Only)
Inventors: BÄR, Thomas; (DE).
MAIER, Thomas; (DE).
BECKERS, Thomas; (DE).
CIOSSEK, Thomas; (DE).
MAHBOOBI, Siavosh; (DE).
SELLMER, Andreas; (DE)
Agent: KILGER, Ute; Boehmert & Boehmert Hollerallee 32 28209 Bremen (DE)
Priority Data:
07022287.2 16.11.2007 EP
Title (EN) NOVEL BIFUNCTIONAL COMPOUNDS WHICH INHIBIT PROTEIN KINASES AND HISTONE DEACETYLASES
(FR) NOUVEAUX COMPOSÉS BIFONCTIONNELS QUI INHIBENT LES PROTÉINES KINASES ET LES HISTONES DÉSACÉTYLASES
Abstract: front page image
(EN)The present invention relates to a bifunctional compound of formula I or its pharmaceutically acceptable salts or solvates A-L-B (I) wherein A is a histone deacetylase (HDAC) inhibitory moiety, L is a single bond or a linker group and B is a protein kinase inhibitory moiety. The bifunctional compound according to formula (I) is useful for the treatment of malignant and non-malignant neoplasia and diseases related to abnormal cell growth.
(FR)La présente invention concerne un composé bifonctionnel de la formule I ou ses sels ou solvates acceptables du point de vue pharmaceutique A-L-B, (I) A étant une fraction inhibitrice d'histones désacétylases (HDAC), L étant une simple liaison ou un groupe de liaison et B étant une fraction inhibitrice de protéines kinases. Le composé bifonctionnel selon la formule (I) s'utilise pour le traitement d'une néoplasie maligne et non maligne et de maladies associées à une croissance cellulaire anormale.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)