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1. (WO2009062989) NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINE DERIVATIVES AND THEIR MEDICAL USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/062989    International Application No.:    PCT/EP2008/065437
Publication Date: 22.05.2009 International Filing Date: 13.11.2008
IPC:
C07D 471/08 (2006.01), A61K 31/551 (2006.01)
Applicants: NEUROSEARCH A/S [DK/DK]; Pederstrupvej 93 DK-2750 Ballerup (DK) (For All Designated States Except US).
PETERS, Dan [SE/DK]; (DK) (For US Only).
TIMMERMANN, Daniel, B. [DK/DK]; (DK) (For US Only).
NIELSEN, Elsebet, Østergaard [DK/DK]; (DK) (For US Only).
OLSEN, Gunnar, M. [DK/DK]; (DK) (For US Only).
DYHRING, Tino [DK/DK]; (DK) (For US Only).
CHRISTENSEN, Jeppe, Kejser [DK/DK]; (DK) (For US Only).
REDROBE, John, Paul [GB/DK]; (DK) (For US Only).
MIKKELSEN, Jens, Damsgaard [DK/DK]; (DK) (For US Only)
Inventors: PETERS, Dan; (DK).
TIMMERMANN, Daniel, B.; (DK).
NIELSEN, Elsebet, Østergaard; (DK).
OLSEN, Gunnar, M.; (DK).
DYHRING, Tino; (DK).
CHRISTENSEN, Jeppe, Kejser; (DK).
REDROBE, John, Paul; (DK).
MIKKELSEN, Jens, Damsgaard; (DK)
Common
Representative:
NEUROSEARCH A/S; Patent Department, Pederstrupvej 93, DK-2750 Ballerup (DK)
Priority Data:
PA 2007 01621 14.11.2007 DK
60/988,119 15.11.2007 US
Title (EN) NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINE DERIVATIVES AND THEIR MEDICAL USE
(FR) NOUVEAUX DÉRIVÉS DE 1,4-DIAZA-BICYCLO[3.2.2]NONYL-PYRIMIDINE ET LEUR UTILISATION À DES FINS MÉDICALES
Abstract: front page image
(EN)This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
(FR)L'invention concerne de nouveaux dérivés de 1,4-diaza-bicyclo[3.2.2]nonyl-pyrimidine et leur utilisation dans la préparation de compositions pharmaceutiques. On a découvert que les composés de l'invention sont des ligands cholinergiques au niveau des récepteurs nicotiniques de l'acétylcholine ainsi que des modulateurs des récepteurs et des transporteurs des monoamines. Du fait de leur profil pharmacologique, les composés de l'invention peuvent être utiles pour traiter des maladies ou des troubles aussi divers que ceux associés au système cholinergique du système nerveux central (SNC) ou au système nerveux périphérique (SNP), des maladies ou des troubles associés à la contraction des muscles lisses, des maladies ou des troubles endocriniens, des maladies ou des troubles associés à une neurodégénérescence, des maladies ou des troubles associés à l'inflammation ou à la douleur, ainsi que les symptômes de sevrage causés par l'arrêt d'une consommation abusive de substances chimiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)