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1. (WO2009062988) NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINE DERIVATIVES AND THEIR MEDICAL USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/062988    International Application No.:    PCT/EP2008/065436
Publication Date: 22.05.2009 International Filing Date: 13.11.2008
IPC:
C07D 471/08 (2006.01)
Applicants: NeuroSearch A/S [DK/DK]; Pederstrupvej 93 DK-2750 Ballerup (DK) (For All Designated States Except US).
PETERS, Dan [SE/DK]; (DK) (For US Only).
TIMMERMANN, Daniel, B. [DK/DK]; (DK) (For US Only).
NIELSEN, Elsebet, Østergaard [DK/DK]; (DK) (For US Only).
OLSEN, Gunnar, M. [DK/DK]; (DK) (For US Only).
DYHRING, Tino [DK/DK]; (DK) (For US Only).
CHRISTENSEN, Jeppe, Kejser [DK/DK]; (DK) (For US Only).
REDROBE, John, Paul [GB/DK]; (DK) (For US Only).
MIKKELSEN, Jens, Damsgaard [DK/DK]; (DK) (For US Only)
Inventors: PETERS, Dan; (DK).
TIMMERMANN, Daniel, B.; (DK).
NIELSEN, Elsebet, Østergaard; (DK).
OLSEN, Gunnar, M.; (DK).
DYHRING, Tino; (DK).
CHRISTENSEN, Jeppe, Kejser; (DK).
REDROBE, John, Paul; (DK).
MIKKELSEN, Jens, Damsgaard; (DK)
Common
Representative:
NeuroSearch A/S; Patent Department, Pederstrupvej 93, DK-2750 Ballerup (DK)
Priority Data:
PA 2007 01620 14.11.2007 DK
60/988,118 15.11.2007 US
Title (EN) NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINE DERIVATIVES AND THEIR MEDICAL USE
(FR) NOUVEAUX DÉRIVÉS DE 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINE ET LEUR UTILISATION MÉDICALE
Abstract: front page image
(EN)This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives of formula (I) and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
(FR)Cette invention concerne de nouveaux dérivés de 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine de la formule (I) et leur utilisation dans la fabrication de compositions pharmaceutiques. Les composés de l'invention se trouvent être des ligands cholinergiques au niveau des récepteurs nicotiniques de l'acétylcholine et des modulateurs des récepteurs et transporteurs de monoamine. En raison de leur profil pharmacologique, les composés de l'invention peuvent être utiles en vue du traitement de maladies et de troubles aussi divers que ceux associés au système cholinergique du système nerveux central (SNC), du système nerveux périphérique (SNP), de maladies ou de troubles associés à la contraction des muscles lisses, de maladies ou de troubles endocriniens, de maladies ou de troubles associés à la neurodégénérescence, de maladies ou de troubles associés à une inflammation, de la douleur, et des symptômes de privation provoqués par l'arrêt de l'abus de substances chimiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)