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1. (WO2009062402) QUINAZOLINONE DERIVATIVES, THE PREPARATION METHODS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/062402    International Application No.:    PCT/CN2008/001859
Publication Date: 22.05.2009 International Filing Date: 07.11.2008
IPC:
C07D 239/91 (2006.01), C07C 237/42 (2006.01), A61K 31/517 (2006.01), A61K 31/505 (2006.01), A61P 15/14 (2006.01), A61P 15/00 (2006.01), A61P 9/12 (2006.01), A61P 27/06 (2006.01), A61P 29/00 (2006.01), A61P 11/08 (2006.01), A61P 13/08 (2006.01), A61P 13/10 (2006.01)
Applicants: TOPHARMAN SHANGHAI CO., LTD. [CN/CN]; 1088 Chuansha Road, Pudong Shanghai 201209 (CN) (For All Designated States Except US).
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES [CN/CN]; 294 Taiyuan Road Shanghai 200031 (CN) (For All Designated States Except US).
SHEN, Jingshan [CN/CN]; (CN) (For US Only).
ZHENG, Jin [CN/CN]; (CN) (For US Only).
LAI, Qinglin [CN/CN]; (CN) (For US Only).
WANG, Zhen [CN/CN]; (CN) (For US Only).
ZHANG, Jinfeng [CN/CN]; (CN) (For US Only).
TIAN, Guanghui [CN/CN]; (CN) (For US Only).
DUAN, Hongliang [CN/CN]; (CN) (For US Only)
Inventors: SHEN, Jingshan; (CN).
ZHENG, Jin; (CN).
LAI, Qinglin; (CN).
WANG, Zhen; (CN).
ZHANG, Jinfeng; (CN).
TIAN, Guanghui; (CN).
DUAN, Hongliang; (CN)
Agent: KINGSOUND & PARTNERS; 11/F, Block B, Kingsound International Center, 116 Zizhuyuan Road, Haidian District Beijing 100097 (CN)
Priority Data:
200710047915.8 07.11.2007 CN
Title (EN) QUINAZOLINONE DERIVATIVES, THE PREPARATION METHODS AND USES THEREOF
(FR) DÉRIVÉS DE QUINAZOLINONE, LEURS PROCÉDÉS DE PRÉPARATION ET LEURS UTILISATIONS
(ZH) 喹唑啉酮衍生物及其制备方法和用途
Abstract: front page image
(EN)The quinzolinone derivatives, the preparation methods and uses thereof. The quinzolinone compounds having the structure of general formula (I), or their pharmaceutical acceptable salts. Most of these compounds have strong activities of inhibiting PDE5, and have highly selectivity of PDE 6 which is distributed on the retina. So the present compounds are expected to exhibit good safety and effectiveness and have broad uses in clinic.
(FR)L'invention concerne des dérivés de quinazolinone, leurs procédés de préparation et leurs utilisations. Les composés de quinazolinone présentent la structure de formule générale (I) ou ses sels pharmaceutiquement acceptables. La plupart de ces composés présentent de fortes activités d'inhibition de PDE5 et une sélectivité élevée de PDE6 qui est distribué sur la rétine. Il est donc prévu que les présents composés présentent une bonne sécurité et une bonne efficacité et puissent être largement utilisés en clinique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)