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1. (WO2009062344) USE OF LYMPHOTOXIN FOR SENSITIZING TUMOR CELLS TO CHEMOTHERAPEUTIC DRUGS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/062344    International Application No.:    PCT/CN2007/003242
Publication Date: 22.05.2009 International Filing Date: 16.11.2007
IPC:
A61K 38/19 (2006.01), A61P 35/00 (2006.01)
Applicants: SHANGHAI FUDAN-ZHANGJIANG BIO-PHARMACEUTICAL CO., LTD. [CN/CN]; No.308 Cailun Road Pudong New Area Shanghai 201210 (CN) (For All Designated States Except US).
LIU, Yanjun [CN/CN]; (CN) (For US Only).
SHEN, Yijun [CN/CN]; (CN) (For US Only).
YANG, Tong [CN/CN]; (CN) (For US Only).
WANG, Jing [CN/CN]; (CN) (For US Only)
Inventors: LIU, Yanjun; (CN).
SHEN, Yijun; (CN).
YANG, Tong; (CN).
WANG, Jing; (CN)
Agent: SHANGHAI L & W INTELLECTUAL PROPERTY LAW OFFICE, LLC; No. 1 Building, Suite 4A 543, Xin Hua Road Shanghai 200052 (CN)
Priority Data:
Title (EN) USE OF LYMPHOTOXIN FOR SENSITIZING TUMOR CELLS TO CHEMOTHERAPEUTIC DRUGS
(FR) UTILISATION DE LYMPHOTOXINE POUR SENSIBILISER DES CELLULES TUMORALES À DES MÉDICAMENTS CHIMIOTHÉRAPEUTIQUES
(ZH) 淋巴毒素在增加肿瘤对化疗药物敏感性中的应用
Abstract: front page image
(EN)Lymphotoxin (LT) is used to sensitize tumor cells of epidermis source to chemotherapeutic drugs. Administration of LT along with chemotherapy has obvious synergic action for killing effect of tumor cells of epidermis source. The tumor is selected from the group consisting of non-cellule lung cancer, breast cancer, laryngocarcinoma, colorectal cancer, carcinoma of uterine cervix, melanoma and gastric cancer. The chemotherapeutic drug is selected from the group consisting of platinum type medicine, anthracene nucleus type medicine, 5-Fluorouracil (5-FU), mitomycin, and any combination thereof.
(FR)Une lymphotoxine (LT) est utilisée pour sensibiliser des cellules tumorales de source épidermique à des médicaments chimiothérapeutiques. L'administration de LT accompagnée d'une chimiothérapie présente une action synergique évidente pour détruire l'effet des cellules tumorales de source épidermique. La tumeur est choisie dans le groupe constitué d'un cancer du poumon non à petites cellules, d'un cancer du sein, d'un laryngocarcinome, d'un cancer colorectal, d'un carcinome du col de l'utérus, d'un mélanome et d'un cancer gastrique. Le médicament chimiothérapeutique est choisi dans le groupe constitué d'un médicament de type platine, d'un médicament de type noyau anthracène, le 5-fluorouracile (5-FU), la mitomycine et toutes leurs combinaisons.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)