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Machine translation
1. (WO2009062095) MICROFLUIDIC DEVICE HAVING STABLE STATIC GRADIENT FOR ANALYZING CHEMOTAXIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/062095    International Application No.:    PCT/US2008/082883
Publication Date: 14.05.2009 International Filing Date: 07.11.2008
IPC:
B01L 3/00 (2006.01), B01F 13/00 (2006.01), B01F 15/04 (2006.01), C12M 3/04 (2006.01)
Applicants: BELLBROOK LABS, LLC [US/US]; 5500 Nobel Drive, Suite 250, Madison, WI 53711 (US) (For All Designated States Except US).
MEYVANTSSON, Ivar [US/US]; (US) (For US Only).
MAJER, John [US/US]; (US) (For US Only).
HAYES, Steven [US/US]; (US) (For US Only)
Inventors: MEYVANTSSON, Ivar; (US).
MAJER, John; (US).
HAYES, Steven; (US)
Agent: VINAROV, Sara, D.; Quarles & Brady LLP, P.O. Box 2113, Madison, WI 53703 (US)
Priority Data:
61/002,247 07.11.2007 US
Title (EN) MICROFLUIDIC DEVICE HAVING STABLE STATIC GRADIENT FOR ANALYZING CHEMOTAXIS
(FR) DISPOSITIF MICROFLUIDIQUE AYANT UN GRADIENT STATIQUE STABLE POUR L'ANALYSE DE LA CHIMIOTAXIE
Abstract: front page image
(EN)A microfluidic method and device for testing and analysing chemotaxis by providing a stable, static fluid gradient. The device includes a sink reservoir (18) for receiving biological cellular' material and a source reservoir (11) for receiving a chemoattractant. The biological cellular material migrates through a low fluid volume microfluidic gradient channel (25) located between the source and sink reservoirs. The fluid in the gradient channel is static and stable due to a high fluid volume closed circuit bypass microfluidic channel (26) also in fluid communication with the source and sink reservoirs, whereby the bypass channel relieves any pressure differential imparted across the gradient channel.
(FR)L'invention concerne un procédé et un dispositif microfluidique pour tester et analyser la chimiotaxie en fournissant un gradient de fluide statique, stable. Le dispositif comprend un réservoir plongeant pour recevoir un matériau cellulaire biologique et un réservoir source pour recevoir un chimioattracteur. Le matériau cellulaire biologique migre vers un canal de gradient microfluidique de faible volume de fluide situé entre les réservoirs source et plongeant. Le fluide dans le canal de gradient est statique et stable du fait d'un canal microfluidique de déviation en circuit fermé de volume de fluide élevé également en communication fluidique avec les réservoirs source et plongeant, le canal de déviation libérant ainsi un différentiel de pression quelconque conféré au canal de gradient.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)