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Machine translation
1. (WO2009062084) CLEAVABLE MODIFICATIONS TO REDUCIBLE POLY(AMIDO ETHYLENIMINE)S TO ENHANCE NUCLEOTIDE DELIVERY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/062084    International Application No.:    PCT/US2008/082869
Publication Date: 14.05.2009 International Filing Date: 07.11.2008
IPC:
C08G 65/48 (2006.01), C08G 65/34 (2006.01), C08G 65/32 (2006.01), C08L 71/00 (2006.01), C08L 71/08 (2006.01), A61K 31/7105 (2006.01), C07H 21/00 (2006.01)
Applicants: UNIVERSITY OF UTAH RESEARCH FOUNDATION [US/US]; 615 Arapeen Drive, Suite 310, Salt Lake City, UT 84108 (US) (For All Designated States Except US).
YOCKMAN, James, W. [US/US]; (US) (For US Only).
BRUMBACH, Jonathan [US/US]; (US) (For US Only).
CHRISTENSEN, Lane, V. [US/US]; (US) (For US Only).
KIM, Sung, Wan [US/US]; (US) (For US Only)
Inventors: YOCKMAN, James, W.; (US).
BRUMBACH, Jonathan; (US).
CHRISTENSEN, Lane, V.; (US).
KIM, Sung, Wan; (US)
Agent: HOWARTH, Alan, J.; Clayton, Howarth & Cannon, P.C., P.O. Box 1909, Sandy, UT 84091 (US)
Priority Data:
61/002,283 07.11.2007 US
Title (EN) CLEAVABLE MODIFICATIONS TO REDUCIBLE POLY(AMIDO ETHYLENIMINE)S TO ENHANCE NUCLEOTIDE DELIVERY
(FR) MODIFICATIONS CLIVABLES DE POLY(AMIDOÉTHYLÈNEIMINE) RÉDUCTIBLES POUR OPTIMISER LA DISTRIBUTION DE NUCLÉOTIDES
Abstract: front page image
(EN)Improved poly(amido ethylenimine) copolymers for gene delivery are disclosed. One illustrative embodiment includes polyethylene glycol (PEG) covalently bonded to a branched poly (triethyenetetramine/cystamine bisacrylamide) copolymer (poly (TETA/CBA) ). The polyethylene glycol can be linear or branched. Another illustrative embodiment includes an RGD peptide covalently bonded to the poly (TETA/CBA) -PEG conjugate. Still another illustrative embodiment includes a method of using these compositions for transfecting a cell with a nucleic acid.
(FR)L'invention concerne des copolymères de poly(amidoéthylèneimine) améliorés pour la distribution de gènes. Un mode de réalisation illustratif comprend du poly(éthylène) glycol (PEG) lié par covalence à un copolymère de poly(triéthylènetétramine/cystamine bisacrylamide) ramifié (poly(TETA/CBA)). Le poly(éthylène) glycol peut être linéaire ou ramifié. Un autre mode de réalisation illustratif comprend un peptide RGD lié par covalence au conjugué poly(TETA/CBA)-PEG. Encore un autre mode de réalisation illustratif comprend un procédé d'utilisation de ces compositions pour transfecter une cellule avec un acide nucléique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)