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1. (WO2009061890) METHODS AND COMPOSITIONS FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF CHRONIC MYELOID LEUKEMIA AND ACUTE LYMPHOBLASTIC LEUKEMIA
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/061890    International Application No.:    PCT/US2008/082592
Publication Date: 14.05.2009 International Filing Date: 06.11.2008
IPC:
C12Q 1/68 (2006.01)
Applicants: ST. JUDE CHILDREN'S RESEARCH HOSPITAL [US/US]; 332 North Lauderdale Street Memphis, TN 38105-2794 (US) (For All Designated States Except US).
DOWNING, James [US/US]; (US) (For US Only).
MULLIGHAN, Charles [AU/US]; (US) (For US Only)
Inventors: DOWNING, James; (US).
MULLIGHAN, Charles; (US)
Agent: WILLIAMSON, Kelly, J.; Alston & Bird LLP Bank Of America Plaza 101 South Tryon Street, Suite 4000 Charlotte, NC 28280-4000 (US)
Priority Data:
60/986,530 08.11.2007 US
61/002,351 08.11.2007 US
61/012,554 10.12.2007 US
Title (EN) METHODS AND COMPOSITIONS FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF CHRONIC MYELOID LEUKEMIA AND ACUTE LYMPHOBLASTIC LEUKEMIA
(FR) PROCÉDÉS ET COMPOSITIONS POUR LE DIAGNOSTIC, LE PRONOSTIC ET LE TRAITEMENT DE LA LEUCÉMIE MYÉLOÏDE CHRONIQUE ET DE LA LEUCÉMIE LYMPHOBLASTIQUE AIGUË
Abstract: front page image
(EN)Compositions and methods for the identification, prognosis, classification, treatment, and diagnosis of leukemia or a genetic predisposition to leukemia are provided. The present invention is based on the discovery of various genomic abnormalities of the IKZFl gene which are shown herein to be associated with acute lymphoblastic leukemia (ALL), more particularly, associated with BCR-ABLl positive ALL and/or shown to be associated with chronic myeloid leukemia (CML), more particularly, associated with blast crisis chronic myeloid leukemia (BC-CML) and/or the likelihood of progression into blastic transformation of CML. These various genomic abnormalities of the IKZFl gene can further be used as prognostic markers to identify a subgroup of ALL having very poor outcomes. Such genomic abnormalities of IKZFl find use in methods and compositions useful in the identification and/or prognosis and/or predisposition and/or treatment of ALL, more particularly, BCR-ABLl positive ALL and/or in the identification and/or prognosis and/or predisposition and/or treatment of CML, more particularly, of BC-CML and/or the likelihood of progression into blastic transformation of CML and/or as prognostic markers to identify a subgroup of ALL having very poor outcomes.
(FR)Une enceinte à fibre optique comprend une enveloppe (23) et un ensemble bobine de câble (25) disposé sur une surface extérieure de l'enveloppe. L'ensemble bobine de câble a une première extrémité détachable (55a) et une seconde extrémité détachable (55b). Les première et seconde extrémités détachables comprennent au moins une zone de faiblesse (85) s'étendant à partir d'un diamètre interne de l'ensemble bobine de câble vers un diamètre externe de l'ensemble bobine de câble. Une plaque de montage (27) est engagée en rotation avec l'ensemble bobine de câble (25) de telle sorte que l'ensemble bobine de câble et l'enveloppe (23) tournent de façon sélective et unitaire autour d'un axe de la plaque de montage.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)