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Machine translation
1. (WO2009061852) MODULATION OF FACTOR 9 EXPRESSION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/061852    International Application No.:    PCT/US2008/082527
Publication Date: 14.05.2009 International Filing Date: 05.11.2008
IPC:
C12N 15/11 (2006.01), A61K 31/7088 (2006.01), A61P 7/02 (2006.01), C07H 21/00 (2006.01), A61P 11/00 (2006.01), A61P 9/04 (2006.01)
Applicants: ISIS PHARMACEUTICALS, INC. [US/US]; 1896 Rutherford Road, Carlsbad, CA 92008 (US) (For All Designated States Except US).
FREIER, Susan, M. [US/US]; (US) (For US Only).
MONIA, Brett, P. [US/US]; (US) (For US Only).
ZHANG, Hong [US/US]; (US) (For US Only).
ZHAO, Chenguang [US/US]; (US) (For US Only)
Inventors: FREIER, Susan, M.; (US).
MONIA, Brett, P.; (US).
ZHANG, Hong; (US).
ZHAO, Chenguang; (US)
Agent: GINGRICH, Brenden; Knobbe Martens Olson & Bear LLP, 2040 Main Street, 14th Floor, Irvine, CA 92614 (US)
Priority Data:
60/986,781 09.11.2007 US
Title (EN) MODULATION OF FACTOR 9 EXPRESSION
(FR) MODULATION DE L'EXPRESSION DU FACTEUR 9
Abstract: front page image
(EN)Disclosed herein are antisense compounds and methods for decreasing Factor 9 and increasing clotting time in an individual in need thereof. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to Factor 9 include thrombosis, embolism, thromoboembolism such as deep vein thrombosis, pulmonary embolism, myocardial infarction, and stroke.
(FR)L'invention concerne des composé antisens et des méthodes pour réduire l'expression du facteur 9 et augmenter le temps de coagulation chez un individu nécessitant un tel traitement. Des exemples d'états pathologiques pouvant être atténués par administration de composés antisens ciblés sur le facteur 9 incluent la thrombose, l'embolie et la thrombo-embolie, et notamment la thrombose veineuse profonde, l'embolie pulmonaire, l'infarctus du myocarde et l'accident vasculaire cérébral.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)