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Machine translation
1. (WO2009061847) METHODS FOR DIAGNOSING AND TREATING PELVIC PAIN DISORDERS VIA BETA-CATENIN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/061847    International Application No.:    PCT/US2008/082520
Publication Date: 14.05.2009 International Filing Date: 05.11.2008
IPC:
G01N 33/48 (2006.01), G01N 33/50 (2006.01)
Applicants: UNIVERSITY OF ROCHESTER [US/US]; 601 Elmwood Avenue Rochester, NY 14642 (US) (For All Designated States Except US).
REEDER, Jay, E. [US/US]; (US) (For US Only).
MAYER, Robert, D. [US/US]; (US) (For US Only).
O'CONNELL, Mary [US/US]; (US) (For US Only)
Inventors: REEDER, Jay, E.; (US).
MAYER, Robert, D.; (US).
O'CONNELL, Mary; (US)
Agent: MERKEL, Edwin, V.; Nixon Peabody LLP, 1100 Clinton Square, Rochester, NY 14604-1792 (US)
Priority Data:
60/985,476 05.11.2007 US
Title (EN) METHODS FOR DIAGNOSING AND TREATING PELVIC PAIN DISORDERS VIA BETA-CATENIN
(FR) PROCÉDÉS DE DIAGNOSTIC ET DE TRAITEMENT DE TROUBLES PELVIENS DOULOUREUX PAR L'INTERMÉDIAIRE DE LA BÊTA-CATÉNINE
Abstract: front page image
(EN)Methods for diagnosing a pelvic pain disorder that include analyzing samples for increased levels and/or nuclear accumulation of beta-catenin, which indicates presence of the pelvic pain disorder, particularly interstitial cystitis. Therapeutic treatment of a pelvic pain disorder, particularly interstitial cystitis, includes the administration to a patient of an effective amount of an inhibitor of beta- catenin activity. This can be carried out by direct administration of the therapeutic agent or via gene therapy.
(FR)L'invention concerne des procédés pour diagnostiquer un trouble pelvien douloureux, qui comprend l'analyse de prélèvements à la recherche de niveaux augmentés et/ou d'une accumulation nucléaire de bêta-caténine, ce qui indique la présence d'un trouble pelvien douloureux, en particulier d'une cystite interstitielle. Un traitement thérapeutique d'un trouble pelvien douloureux, en particulier de la cystite interstitielle, comprend l'administration au patient d'une quantité efficace d'un inhibiteur de l'activité de la bêta-caténine. Ceci peut être mis en œuvre par l'administration directe de l'agent thérapeutique ou par l'intermédiaire d'une thérapie génique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)