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Machine translation
1. (WO2009061596) COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/061596    International Application No.:    PCT/US2008/080176
Publication Date: 14.05.2009 International Filing Date: 16.10.2008
IPC:
C07D 231/54 (2006.01), C07D 471/00 (2006.01), C07D 493/00 (2006.01), A61K 31/415 (2006.01), A61P 35/00 (2006.01)
Applicants: SCHERING CORPORATION [US/US]; 2000 Galloping Hill Road, Kenilworth, New Jersey 07033-0530 (US) (For All Designated States Except US).
SIDDIQUI, Arshad, M. [CA/US]; (US) (For US Only).
DAI, Chaoyang [CA/US]; (US) (For US Only).
MANSOOR, Umar Faruk [GB/US]; (US) (For US Only).
YANG, Liping [CN/US]; (US) (For US Only).
VITHARANA, Lalalnthi, Dilrukshi [LK/US]; (US) (For US Only).
ANGELES, Angie R. [US/US]; (US) (For US Only).
SHIPPS, Gerald W., Jr. [US/US]; (US) (For US Only).
HUANG, Xiaohua [CN/US]; (US) (For US Only).
CHENG, Cliff [CN/US]; (US) (For US Only)
Inventors: SIDDIQUI, Arshad, M.; (US).
DAI, Chaoyang; (US).
MANSOOR, Umar Faruk; (US).
YANG, Liping; (US).
VITHARANA, Lalalnthi, Dilrukshi; (US).
ANGELES, Angie R.; (US).
SHIPPS, Gerald W., Jr.; (US).
HUANG, Xiaohua; (US).
CHENG, Cliff; (US)
Agent: MACMILLAN, Keith D.; Schering-plough Corporation, Patent Department, K-6-1 1990, 2000 Galloping Hill Road, Kenilworth, New Jersey 07033-0530 (US)
Priority Data:
60/986,799 09.11.2007 US
Title (EN) COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY
(FR) COMPOSÉS POUR INHIBER L'ACTIVITÉ DE LA KINÉSINE KSP
Abstract: front page image
(EN)The present invention relates to compounds of Formula (I), below, (wherein X, R1, R2, R3, R27, R28, p, E, ring A, and ring B are as defined herein). The present invention also relates to compositions (including pharmaceutically acceptable compositions) comprising these compounds, alone and in combination with one or more additional therapeutic agents, and to methods for their use in inhibiting KSP kinesin activity, and for treating cellular proliferative diseases or disorders associated with KSP kinesin activity.
(FR)La présente invention porte sur des composés représentés par la Formule (I), ci-après, (dans laquelle X, R1, R2, R3, R27, R28, p, E, le cycle A et le cycle B sont tels que définis présentement). La présente invention porte également sur des compositions (comprenant des compositions pharmaceutiquement acceptables) comprenant ces composés, individuellement ou en association avec un ou plusieurs agents thérapeutiques supplémentaires, et sur des procédés permettant de les utiliser dans l'inhibition de l'activité de la kinésine de KSP et pour traiter des maladies ou troubles de la prolifération cellulaire associés avec une activité de la kinésine KSP.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)