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1. (WO2009061529) (+)-ENANTIOMER OF 5-PYRROLYL-2-PYRIDYLMETHYLSULFINYL BENZIMIDAZOLE AND PROCESSING METHOD EOR PREPARING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/061529    International Application No.:    PCT/US2008/065517
Publication Date: 14.05.2009 International Filing Date: 02.06.2008
IPC:
A01N 43/40 (2006.01)
Applicants: TAP PHARMACEUTICAL PRODUCTS, INC. [--/US]; 675 North Field Drive, Lake Forest, Illinois 60045 (US) (For All Designated States Except US).
KIM, Dong-yeon [KR/KR]; (KR) (For US Only).
KIM, Jae-gun [KR/KR]; (KR) (For US Only).
LEE, Jun-yeoun [KR/KR]; (KR) (For US Only).
CHO, Kwi-hyung [KR/KR]; (KR) (For US Only).
KIM, Jung-Woo [KR/KR]; (KR) (For US Only).
PARK, Sung-tae [KR/KR]; (KR) (For US Only).
PYUN, Doo-hyuk [KR/KR]; (KR) (For US Only).
NAM, Sang-don [KR/KR]; (KR) (For US Only).
YOON, Hwan-min [KR/KR]; (KR) (For US Only).
HAN, Byoungcheol [--/KR]; (KR) (For US Only)
Inventors: KIM, Dong-yeon; (KR).
KIM, Jae-gun; (KR).
LEE, Jun-yeoun; (KR).
CHO, Kwi-hyung; (KR).
KIM, Jung-Woo; (KR).
PARK, Sung-tae; (KR).
PYUN, Doo-hyuk; (KR).
NAM, Sang-don; (KR).
YOON, Hwan-min; (KR).
HAN, Byoungcheol; (KR)
Agent: ZINKL, Gregory M.; Dykema Gossett PLLC, 10 South Wacker Drive, Suite 2300, Chicago, Illinois 60606 (US)
Priority Data:
11/935,873 06.11.2007 US
Title (EN) (+)-ENANTIOMER OF 5-PYRROLYL-2-PYRIDYLMETHYLSULFINYL BENZIMIDAZOLE AND PROCESSING METHOD EOR PREPARING THE SAME
(FR) ENANTIOMÈRE (+)- DU 5-PYRROLYL-2-PYRIDYLMÉTHYLSULFINYL BENZIMIDAZOLE ET PROCÉDÉ DE TRAITEMENT POUR SA PRÉPARATION
Abstract: front page image
(EN)The present invention relates to (+)-enantiomer of 5-pyrrolyl-2-pyridylmethylsulfinyl benzimidazole, and a preparing method thereof. Specifically, the present invention relates to (+)-enantiomer of formula (1) and a process for preparing the (+)-enantiomer by using chiral auxiliary, comprising the step of reacting the compound of formula (2), 2-[[(4-methoxy-3-methyl)-2-pyridinyl]methylthio]-5-(1H-pyrrol-1-yl)-1H]benzimidazole, wth diisopropyl L-tartate, which is not used for known proton inhibitory compounds but shows a superior reactivty to the compound of formula (2), or chiral auxiliary selected from (R)-(+)-1,1'-bi-2-naphthol; and the step of crystallizing the product of the above step.
(FR)La présente invention porte sur l'énantiomère (+) du 5-pyrrolyl-2-pyridylméthylsulfinyl benzimidazole, et sur son procédé de préparation. De manière spécifique, la présente invention porte sur un énantiomère (+)- de formule (1) et sur un procédé pour préparer l'énantiomère (+)- à l'aide d'un auxiliaire chiral, comprenant l'étape de réaction du composé de formule (2), 2-[[(4-méthoxy-3-méthyl)-2-pyridinyl]méthylthio]-5-(1H-pyrrol-1-yl)-1H]benzimidazole, avec du diisopropyl L-tartate, qui n'est pas utilisé pour des composés inhibiteurs de protons connus mais qui montre une réactivité supérieure au composé de formule (2), ou un auxiliaire chiral choisi parmi (R)-(+)-1,1'-bi-2-naphthol ; et l'étape de cristallisation du produit de l'étape précédente.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)