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Machine translation
1. (WO2009061498) CYCLIC UREA INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE 1
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/061498    International Application No.:    PCT/US2008/012618
Publication Date: 14.05.2009 International Filing Date: 07.11.2008
IPC:
C07D 239/10 (2006.01), C07D 401/04 (2006.01), C07D 401/10 (2006.01), C07D 403/06 (2006.01), C07D 409/04 (2006.01), C07D 409/10 (2006.01), C07D 417/10 (2006.01), A61K 31/513 (2006.01), A61K 31/5377 (2006.01), A61P 3/00 (2006.01), A61P 27/06 (2006.01), A61P 9/00 (2006.01)
Applicants: VITAE PHARMACEUTICALS, INC. [US/US]; 502 West Office Center Drive Fort Washington, PA 19034 (US) (For All Designated States Except US).
CLAREMON, David, A. [US/US]; (US) (For US Only).
ZHUANG, Linghang [CN/US]; (US) (For US Only).
TICE, Colin, M. [US/US]; (US) (For US Only).
YE, Yuanjie [CN/US]; (US) (For US Only).
HE, Wei [US/US]; (US) (For US Only).
SINGH, Suresh, B. [US/US]; (US) (For US Only).
XU, Zhenrong [CN/US]; (US) (For US Only).
CACATIAN, Salvacion [US/US]; (US) (For US Only).
ZHAO, Wei [CN/US]; (US) (For US Only)
Inventors: CLAREMON, David, A.; (US).
ZHUANG, Linghang; (US).
TICE, Colin, M.; (US).
YE, Yuanjie; (US).
HE, Wei; (US).
SINGH, Suresh, B.; (US).
XU, Zhenrong; (US).
CACATIAN, Salvacion; (US).
ZHAO, Wei; (US)
Agent: DAVIS, Steven, G.; FOLEY & LARDNER LLP 111 Huntington Avenue Boston, MA 02199 (US)
Priority Data:
61/002,157 07.11.2007 US
Title (EN) CYCLIC UREA INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE 1
(FR) INHIBITEURS DE L'URÉE CYCLIQUE DE LA 11Β-HYDROXYSTÉROÏDE DÉSHYDROGÉNASE 1
Abstract: front page image
(EN)This invention relates to novel compounds of the Formula (I), (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih)1 (Ij), (Ik), (II1-3). (Im1-3), (In1-3), (lo1-2), (Ip1-6), (Iq1-6), (Ir1-6) and (Is1-2), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.
(FR)L'invention porte sur les nouveaux composés représentés par les Formules (I), (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ij), (Ik), (II1-3). (Im1-3), (In1-3), (Io1-2), (Ip1-6), (Iq1-6), (Ir1-6) et (Is1-2), sur des sels pharmaceutiquement acceptables de ceux-ci, et sur des compositions pharmaceutiques de ces composés et de leurs sels, qui sont utiles pour le traitement thérapeutique de maladies associées à la modulation ou à l'inhibition de la 11 β-HSD1 chez les mammifères. L'invention porte en outre sur des compositions pharmaceutiques des nouveaux composés et sur des procédés pour leur utilisation dans la réduction ou le contrôle de la production de cortisol dans une cellule ou l'inhibition de la conversion de cortisone en cortisol dans une cellule.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)