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Machine translation
1. (WO2009061446) METHODS OF ADMINISTERING N-(5-TERT-BUTYL-ISOXAZOL-3-YL)-N'-{4-[7-(2-MORPHOLIN-4-YL-ETHOXY)IMIDAZO[2,1-B][1,3]BENZOTHIAZOL-2-YL]PHENYL}UREA TO TREAT PROLIFERATIVE DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/061446    International Application No.:    PCT/US2008/012539
Publication Date: 14.05.2009 International Filing Date: 07.11.2008
IPC:
A61K 31/5377 (2006.01), A61P 35/00 (2006.01), A61P 35/02 (2006.01)
Applicants: AMBIT BIOSCIENCES CORP. [US/US]; 4215 Sorrento Valley Blvd. San Diego, CA 92121 (US) (For All Designated States Except US).
JAMES, Joyce, K. [US/US]; (US) (For US Only).
SAVALL, Traci L. [US/US]; (US) (For US Only).
EICHELBERGER, Shawn R. [US/US]; (US) (For US Only)
Inventors: JAMES, Joyce, K.; (US).
SAVALL, Traci L.; (US).
EICHELBERGER, Shawn R.; (US)
Agent: INSOGNA, Anthony, M.; Jones Day 222 East 41st Street New York, NY 10017-6702 (US)
Priority Data:
61/002,583 08.11.2007 US
61/005,803 07.12.2007 US
61/098,676 19.09.2008 US
61/112,060 06.11.2008 US
Title (EN) METHODS OF ADMINISTERING N-(5-TERT-BUTYL-ISOXAZOL-3-YL)-N'-{4-[7-(2-MORPHOLIN-4-YL-ETHOXY)IMIDAZO[2,1-B][1,3]BENZOTHIAZOL-2-YL]PHENYL}UREA TO TREAT PROLIFERATIVE DISEASE
(FR) PROCÉDÉS D'ADMINISTRATION DE N-(5-TERT-BUTYL-ISOXAZOL-3-YL)-N'-{4-[7-(2-MORPHOLIN-4-YL-ÉTHOXY)IMIDAZO[2,1-B][1,3]BENZOTHIAZOL-2-YL]PHÉNYL}URÉE POUR TRAITER UNE MALADIE PROLIFÉRATIVE
Abstract: front page image
(EN)Provided herein are methods of administering N-(5-tert-butyl-isoxazol-3-yl)- N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, or a pharmaceutically acceptable salt or solvate thereof, to human patients. Specifically, dosing, dosing schedules or dosing regimens are provided herein. Further, pharmaceutical formulations are provided. Methods of treating proliferative diseases or FLT-3 mediated diseases in humans are also provided.
(FR)L'invention porte sur des procédés consistant à administrer de la N-(5-tert-butyl-isoxazol-3-yl)- N'-{4-[7-(2-morpholin-4-yl-éthoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phényl}urée, ou un sel pharmaceutiquement acceptable ou solvate de celle-ci, à des patients humains. De façon spécifique, l'invention porte sur un dosage, des programmes de dosage ou des régimes de dosage. En outre, l'invention porte sur des formulations pharmaceutiques. L'invention porte sur des procédés de traitement de maladies prolifératives ou de maladies à médiation par FLT-3 chez des êtres humains.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)