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1. (WO2009061131) NOVEL TRICYCLIC DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/061131    International Application No.:    PCT/KR2008/006527
Publication Date: 14.05.2009 International Filing Date: 06.11.2008
IPC:
C07D 495/04 (2006.01)
Applicants: JE IL PHARMACEUTICAL CO., LTD. [KR/KR]; 745-5, Banpo 1-dong, Seocho-gu, Seoul 137-810 (KR) (For All Designated States Except US).
KIM, Myung-Hwa [KR/KR]; (KR) (For US Only).
KIM, Seung Hyun [KR/KR]; (KR) (For US Only).
PARK, Chun-Ho [KR/KR]; (KR) (For US Only).
JOE, Bo-Young [KR/KR]; (KR) (For US Only).
CHUN, Kwangwoo [KR/KR]; (KR) (For US Only).
OH, Byung-Kyu [KR/KR]; (KR) (For US Only).
CHOI, Jong-Hee [KR/KR]; (KR).
RYU, Dongkyu [KR/KR]; (KR) (For US Only).
WON, Ran [KR/KR]; (KR) (For US Only).
PARK, Ji-Seon [KR/KR]; (KR) (For US Only).
KIM, Kwang Hee [KR/KR]; (KR) (For US Only).
LEE, Han-Chang [KR/KR]; (KR) (For US Only).
CHOI, Ji Soo [KR/KR]; (KR) (For US Only)
Inventors: KIM, Myung-Hwa; (KR).
KIM, Seung Hyun; (KR).
PARK, Chun-Ho; (KR).
JOE, Bo-Young; (KR).
CHUN, Kwangwoo; (KR).
OH, Byung-Kyu; (KR).
CHOI, Jong-Hee; (KR).
RYU, Dongkyu; (KR).
WON, Ran; (KR).
PARK, Ji-Seon; (KR).
KIM, Kwang Hee; (KR).
LEE, Han-Chang; (KR).
CHOI, Ji Soo; (KR)
Agent: SON, Min; 6th Floor, City Air Tower 159-9, Samseong-dong, Gangnam-gu, Seoul, 135-973 (KR)
Priority Data:
10-2007-0112573 06.11.2007 KR
Title (EN) NOVEL TRICYCLIC DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
(FR) NOUVEAUX DÉRIVÉS TRICYCLIQUES OU LEURS SELS PHARMACEUTIQUEMENT ACCEPTABLES, PROCÉDÉ DE PRÉPARATION DE CES DERNIERS ET COMPOSITION PHARMACEUTIQUE LES CONTENANT
Abstract: front page image
(EN)The present invention relates to novel tricyclic derivatives having an excellent inhibitory activity on poly (ADP-ribose) polymerase, or pharmaceutically acceptable salts thereof, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The tricyclic derivatives of the present invention inhibit the activity of poly (ADP-ribose) polymerase, thereby being used for the prevention or treatment of diseases that are caused by excessive activation of PARP, in particular, neuropathic pain, neurodegenerative diseases, cardiovascular diseases, diabetic neuropathic pain, inflammatory diseases, osteoporosis, and cancer.
(FR)La présente invention concerne de nouveaux dérivés tricycliques qui présentent une excellente activité inhibitrice envers la poly (ADP-ribose) polymérase ou leurs sels pharmaceutiquement acceptables, un procédé de préparation de ces derniers et une composition pharmaceutique les contenant. Les dérivés tricycliques selon la présente invention inhibent l'activité de la poly (ADP-ribose) polymérase, et sont par conséquent utilisés pour la prévention ou le traitement des maladies qui sont provoquées par l'activation excessive de PARP, notamment la douleur neuropathique, les maladies neurodégénératives, les maladies cardiovasculaires, la douleur neuropathique diabétique, les maladies inflammatoires, l'ostéoporose et le cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: Korean (KO)