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1. (WO2009060982) CANCER CELL DEATH INDUCER HAVING ACTIVITY OF POTENTIATING ANTI-CANCER AGENT IN CANCER HAVING RESISTANCE AGAINST THE ANTI-CANCER AGENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/060982    International Application No.:    PCT/JP2008/070541
Publication Date: 14.05.2009 International Filing Date: 05.11.2008
IPC:
A61K 48/00 (2006.01), A61K 31/713 (2006.01), A61K 35/76 (2006.01), A61P 35/00 (2006.01), A61P 35/02 (2006.01), C12N 15/09 (2006.01)
Applicants: MOMOTARO-GENE INC. [JP/JP]; 7-30-6, Tsushima-Fukui 1-chome, Kita-ku, Okayama-shi, Okayama 7000080 (JP) (For All Designated States Except US).
KUMON, Hiromi [JP/JP]; (JP) (For US Only).
NASU, Yasutomo [JP/JP]; (JP) (For US Only).
WATANABE, Masami [JP/JP]; (JP) (For US Only).
KASHIWAKURA, Yuji [JP/JP]; (JP) (For US Only).
KAWASAKI, Kensuke [JP/JP]; (JP) (For US Only)
Inventors: KUMON, Hiromi; (JP).
NASU, Yasutomo; (JP).
WATANABE, Masami; (JP).
KASHIWAKURA, Yuji; (JP).
KAWASAKI, Kensuke; (JP)
Agent: HIRAKI, Yusuke; Kamiya-cho MT Bldg. 19F, 3-20 Toranomon 4-chome, Minato-ku Tokyo 1050001 (JP)
Priority Data:
2007-287373 05.11.2007 JP
Title (EN) CANCER CELL DEATH INDUCER HAVING ACTIVITY OF POTENTIATING ANTI-CANCER AGENT IN CANCER HAVING RESISTANCE AGAINST THE ANTI-CANCER AGENT
(FR) INDUCTEUR DE MORT DE CELLULES CANCÉREUSES AYANT UNE ACTIVITÉ DE POTENTIALISATION D'AGENT ANTI-CANCÉREUX DANS UN CANCER PRÉSENTANT UNE RÉSISTANCE CONTRE L'AGENT ANTI-CANCÉREUX
(JA) 抗癌剤耐性癌において抗癌剤増強作用を有する癌細胞死誘導剤
Abstract: front page image
(EN)Disclosed is a substance capable of recovering the sensitivity of a cancer cell to an anti-cancer agent and inducing the cell death of the cancer cell in cancer acquiring the resistance to the anti-cancer agent. Specifically disclosed is a cancer cell death inducer for a cancer cell having the resistance against an anti-cancer agent, which comprises DNA for REIC/Dkk-3 as an active ingredient, and which has an activity of potentiating the anti-cancer agent.
(FR)L'invention porte sur une substance capable de récupérer la sensibilité d'une cellule cancéreuse à un agent anti-cancéreux et d'induire la mort cellulaire de la cellule cancéreuse dans un cancer ayant acquis une résistance à l'agent anti-cancéreux. De façon précise, l'invention porte sur un inducteur de la mort d'une cellule cancéreuse pour une cellule cancéreuse présentant une résistance contre un agent anti-cancéreux, qui comprend de l'ADN pour REIC/Dkk-3 en tant qu'ingrédient actif, et qui a une activité de potentialisation de l'agent anti-cancéreux.
(JA)抗癌剤耐性を獲得した癌において、癌細胞の抗癌剤感受性を回復させ、かつ癌細胞の細胞死を誘導する薬剤の提供。REIC/Dkk-3のDNAを有効成分として含む、抗癌剤耐性を有する癌細胞用の抗癌剤増強作用を有する癌細胞死誘導剤。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)