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1. (WO2009060963) PROCESS FOR PRODUCTION OF 4-HYDROXYISOLEUCINE OR 2-AMINO-3-METHYL-4-KETOPENTANOIC ACID
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/060963    International Application No.:    PCT/JP2008/070356
Publication Date: 14.05.2009 International Filing Date: 07.11.2008
IPC:
C12N 15/09 (2006.01), C12P 13/06 (2006.01)
Applicants: AJINOMOTO CO., INC. [JP/JP]; 15-1, Kyobashi 1-chome, Chuo-ku, Tokyo 1048315 (JP) (For All Designated States Except US).
KODERA, Tomohiro [JP/JP]; (JP) (For US Only).
SHIMIZU, Sakayu [JP/JP]; (JP) (For US Only).
OGAWA, Jun [JP/JP]; (JP) (For US Only).
HIBI, Makoto [JP/JP]; (JP) (For US Only).
SMIRNOV, Sergey Vasilievich [RU/RU]; (RU) (For US Only).
SAMSONOVA, Natalia Nikolaevna [RU/RU]; (RU) (For US Only).
KOTOLIAROVA, Veronika Aleksandrovna [RU/RU]; (RU) (For US Only).
RUSHKEVICH, Natalia Yurievna [RU/RU]; (RU) (For US Only).
KOZLOV, Ivan Yakovlevich [RU/RU]; (RU) (For US Only).
ARSATYANTS, Raisa Aleksandrovna [RU/RU]; (RU) (For US Only)
Inventors: KODERA, Tomohiro; (JP).
SHIMIZU, Sakayu; (JP).
OGAWA, Jun; (JP).
HIBI, Makoto; (JP).
SMIRNOV, Sergey Vasilievich; (RU).
SAMSONOVA, Natalia Nikolaevna; (RU).
KOTOLIAROVA, Veronika Aleksandrovna; (RU).
RUSHKEVICH, Natalia Yurievna; (RU).
KOZLOV, Yury Ivanovich;
Agent: KAWAGUCHI, Yoshiyuki; Acropolis 21 Building 6th floor 4-10, Higashi Nihonbashi 3-chome Chuo-ku, Tokyo 1030004 (JP)
Priority Data:
2007-290136 07.11.2007 JP
2007140878 07.11.2007 RU
2007140881 07.11.2007 RU
Title (EN) PROCESS FOR PRODUCTION OF 4-HYDROXYISOLEUCINE OR 2-AMINO-3-METHYL-4-KETOPENTANOIC ACID
(FR) PROCÉDÉ DE FABRICATION DE 4-HYDROXYISOLEUCINE OU D'ACIDE 2-AMINO-3-MÉTHYL-4-CÉTOPENTANOÏQUE
(JA) 4-ヒドロキシイソロイシン又は2-アミノ-3-メチル-4-ケトペンタン酸の製造法
Abstract: front page image
(EN)Disclosed is a process for producing 4-hydroxyisoleucine or a salt thereof, which is characterized by comprising the step of subjecting 2-amino-3-methyl-4-ketopentanoic acid or a salt thereof to the reduction reaction in the presence of an enzyme derived from a microorganism capable of producing 4-hydroxyisoleucine from 2-amino-3-methyl-4-ketopentanoic acid to thereby produce 4-hydroxyisoleucine. Also disclosed is a process for producing 2-amino-3-methyl-4-ketopentanoic acid or a salt thereof, which comprises the step of reacting L-isoleucine in the presence of L-isoleucine dioxygenase and 4-hydroxy-L-isoleucine dehydrogenase. Further disclosed is a process for producing (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof from L-isoleucine in the presence of a bacterium which has an L-isoleucine dioxygenase activity and which is so modified that its 4-hydroxy-L-isoleucine dehydrogenase activity is reduce or eliminated.
(FR)L'invention concerne un procédé de fabrication de 4-hydroxyisoleucine ou d'un sel de celle-ci, qui est caractérisé en ce qu'il consiste à soumettre de l'acide 2-amino-3-méthyl-4-cétopentanoïque ou un sel de celui-ci à la réaction de réduction en présence d'une enzyme issue d'un microorganisme capable de produire de la 4-hydroxyisoleucine à partir de l'acide 2-amino-3-méthyl-4-cétopentanoïque pour produire de cette façon de la 4-hydroxyisoleucine. L'invention concerne également un procédé de fabrication d'acide 2-amino-3-méthyl-4-cétopentanoïque ou d'un sel de celui-ci, qui consiste à faire réagir de la L-isoleucine en présence de L-isoleucine dioxygénase et de 4-hydroxy-L-isoleucine déshydrogénase. L'invention concerne également un procédé de fabrication de (2S,3R,4S)-4-hydroxy-L-isoleucine ou d'un sel de celle-ci à partir de L-isoleucine en présence d'une bactérie qui a une activité de L-isoleucine dioxygénase et qui est modifiée de telle sorte que son activité de 4-hydroxy-L-isoleucine déshydrogénase est réduite ou supprimée.
(JA) 2-アミノ-3-メチル-4-ケトペンタン酸から4-ヒドロキシイソロイシンを生成する、微生物由来の酵素の存在下で2-アミノ-3-メチル-4-ケトペンタン酸またはその塩を還元反応に供し4-ヒドロキシイソロイシンを生成させる工程を含むことを特徴とする、4-ヒドロキシイソロイシン又はその塩の製造方法。L-イソロイシンジオキシゲナーゼ及び4-ヒドロキシ-L-イソロイシンデヒドロゲナーゼの存在下で、L-イソロイシンを反応させる工程を含む、2-アミノ-3-メチル-4-ケトペンタン酸又はその塩を製造する方法。4-ヒドロキシ-L-イソロイシンデヒドロゲナーゼの活性が低減又は欠失するように改変されている、L-イソロイシンジオキシゲナーゼ活性を有する細菌の存在下で、L-イソロイシンから(2S,3R,4S)-4-ヒドロキシ-L-イソロイシン又はその塩を製造する方法。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)