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1. (WO2009060601) AGENT FOR TREATMENT OF MALIGNANT TUMOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/060601    International Application No.:    PCT/JP2008/003193
Publication Date: 14.05.2009 International Filing Date: 05.11.2008
Chapter 2 Demand Filed:    04.03.2009    
IPC:
A61K 31/225 (2006.01), A61P 35/00 (2006.01), C07J 63/00 (2006.01)
Applicants: NIHON UNIVERSITY [JP/JP]; 8-24, Kudan-minami 4-chome, Chiyoda-ku, Tokyo 1028275 (JP) (For All Designated States Except US).
SUZUKI, Takashi [JP/JP]; (JP) (For US Only).
AKIHISA, Toshihiro [JP/JP]; (JP) (For US Only).
TABATA, Keiichi [JP/JP]; (JP) (For US Only).
UKIYA, Motohiko [JP/JP]; (JP) (For US Only)
Inventors: SUZUKI, Takashi; (JP).
AKIHISA, Toshihiro; (JP).
TABATA, Keiichi; (JP).
UKIYA, Motohiko; (JP)
Agent: THE PATENT CORPORATE BODY ARUGA PATENT OFFICE; Kyodo Bldg. 3-6, Nihonbashiningyocho 1-chome Chuo-ku, Tokyo 1030013 (JP)
Priority Data:
2007-288387 06.11.2007 JP
Title (EN) AGENT FOR TREATMENT OF MALIGNANT TUMOR
(FR) AGENT DE TRAITEMENT DE TUMEURS MALIGNES
(JA) 悪性腫瘍治療薬
Abstract: front page image
(EN)Disclosed is a novel derivative having remarkable curative effects on malignant tumors, for which a natural triterpene compound serves as a lead compound. Specifically disclosed is an agent for treatment of malignant tumors, which contains a faradiol derivative represented by the general formula (1) below or a salt thereof. (In the formula, R1 and R2 may be the same or different and each represents a linear or branched chain alkylene group having 2-8 carbon atoms.)
(FR)L'invention concerne un nouveau dérivé qui possède des effets curatifs remarquables sur les tumeurs malignes et dont un composé tête de série est un composé triterpénique naturel. Elle concerne spécifiquement un agent de traitement de tumeurs malignes qui contient un dérivé de faradiol représenté par la formule générale (1) ci-dessous ou un de ses sels. (Dans la formule, R1 et R2 peuvent être identiques ou différents et chacun représente un groupe alkylène à chaîne linéaire ou ramifiée contenant de 2 à 8 atomes de carbone.)
(JA) 天然トリテルペン系化合物をリード化合物として、強力な悪性腫瘍治療作用を有する新たな誘導体を提供。  次の一般式(1) (式中、R及びRは同一又は異なって、炭素数2~8の直鎖又は分岐鎖アルキレン基を示す) で表されるファラジオール誘導体又はその塩を含有する悪性腫瘍治療薬。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)