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1. (WO2009060457) NOVEL SYNTHETIC ANALOGS OF SPHINGOLIPIDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/060457    International Application No.:    PCT/IL2008/001472
Publication Date: 14.05.2009 International Filing Date: 09.11.2008
IPC:
C07C 215/10 (2006.01), A61P 35/00 (2006.01), A61P 43/00 (2006.01)
Applicants: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD. [IL/IL]; Hi Tech Park Edmond Safra campus Givat Ram Jerusalem 91390 (IL) (For All Designated States Except US).
HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD. [IL/IL]; P.O.Box 12000, 91120 Jerusalem (IL) (For All Designated States Except US).
DAGAN, Arieh [IL/IL]; (IL) (For US Only).
SLAVIN, Shimon [IL/IL]; (IL) (For US Only).
GATT, Shimon [IL/IL]; (IL) (For US Only).
ZAHAVI, Jeremy [IL/IL]; (IL) (For US Only)
Inventors: DAGAN, Arieh; (IL).
SLAVIN, Shimon; (IL).
GATT, Shimon; (IL).
ZAHAVI, Jeremy; (IL)
Agent: REINHOLD COHN & PARTNERS; P.O.B. 13239 Tel-Aviv 61131 (IL)
Priority Data:
187247 08.11.2007 IL
Title (EN) NOVEL SYNTHETIC ANALOGS OF SPHINGOLIPIDS
(FR) NOUVEAUX ANALOGUES SYNTHÉTIQUES DE SPHINGOLIPIDES
Abstract: front page image
(EN)The present invention provides new ceramide analogs indicated as the compounds of formula (II). These novel analogs exhibit a significant anti cancerous effect and are therefore provided as a pharmaceutical composition for treating cell proliferative diseases, neurodegenerative disorders, metabolism-associated conditions, infectious diseases, and immune-related disorders. The invention further provides combined compositions and kits combining the novel ceramide analogs of formula (II) with an additional therapeutic agent.
(FR)La présente invention propose de nouveaux analogues de céramides indiqués comme étant les composés représentés par la formule (II). Ces nouveaux analogues présentent un effet anti-cancéreux significatif et sont donc fournis sous forme d'une composition pharmaceutique pour le traitement de maladies de prolifération cellulaire, de troubles dégénératifs du système nerveux, d'affections associées au métabolisme, de maladies infectieuses et de troubles se rapportant à l'immunité. L'invention propose également des compositions et des kits combinés qui combinent les nouveaux analogues de céramides de formule (II) avec un agent thérapeutique supplémentaire.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)