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1. (WO2009060318) POLYMORPHIC FORMS OF RAMELTEON AND PROCESSES FOR PREPARATION THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/060318    International Application No.:    PCT/IB2008/003799
Publication Date: 14.05.2009 International Filing Date: 14.07.2008
IPC:
C07D 307/77 (2006.01), A61K 31/343 (2006.01), A61P 25/20 (2006.01)
Applicants: TEVA PHARMACEUTICAL INDUSTRIES LTD. [IL/IL]; 5 BASEL Street P.O. Box 3190 49131 Petach-Tikva (IL) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BE, BF, BG, BH, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
PERLMAN, Nurit [IL/IL]; (IL) (For US Only).
RAFILOVICH, Michal [IL/IL]; (IL) (For US Only).
MOSHKOVITS-KAPTSAN, Rinat [IL/IL]; (IL) (For US Only).
ARONHIME, Judith [IL/IL]; (IL) (For US Only).
BEN MOHA-LERMAN, Elena [IL/IL]; (IL) (For US Only).
LIFSHITZ-LIRON, Revital [IL/IL]; (IL) (For US Only).
TEVA PHARMACEUTICALS USA, INC. [US/US]; 1090 HORSHAM ROAD, P.O. Box 1090, North Wales, Pennsylvania 19454-1090 (US) (BB only)
Inventors: PERLMAN, Nurit; (IL).
RAFILOVICH, Michal; (IL).
MOSHKOVITS-KAPTSAN, Rinat; (IL).
ARONHIME, Judith; (IL).
BEN MOHA-LERMAN, Elena; (IL).
LIFSHITZ-LIRON, Revital; (IL)
Agent: BIRDE, Patrick, J.; Kenyon & Kenyon LLP, One Broadway, NY, New York, 10004-1007 (US)
Priority Data:
60/959,405 12.07.2007 US
61/073,221 17.06.2008 US
Title (EN) POLYMORPHIC FORMS OF RAMELTEON AND PROCESSES FOR PREPARATION THEREOF
(FR) FORMES POLYMORPHES DE RAMELTÉON ET LEURS PROCÉDÉS DE PRÉPARATION
Abstract: front page image
(EN)An amorphous form of ramelteon is provided, as well as mixtures of amorphous and crystalline ramelteon. Also provided are methods of preparing amorphous ramelteon and mixtures of amorphous and crystalline ramelteon, pharmaceutical compositions comprising amorphous ramelteon and mixtures of amorphous and crystalline ramelteon, and methods of treatment of insomnia using the compositions of the invention. (S)-N-[2-(1,6,7,8-tetrahydro-2H-indeno-[5,4-b]furan-8-yl)ethyl]propionainide, whose international nonproprietary name is ramelteon, has the following chemical structure Formula (I). Ramelteon is a melatonin receptor agonist with both high affinity for melatonin MT1 and MT2 receptors and selectivity over the MT3 receptor.
(FR)L'invention propose une forme amorphe de rameltéon, ainsi que des mélanges de rameltéon amorphe et cristallin. L'invention propose également des procédés de préparation de rameltéon amorphe et de mélanges de rameltéon amorphe et cristallin, des compositions pharmaceutiques comportant du rameltéon amorphe et des mélanges de rameltéon amorphe et cristallin, et des procédés de traitement de l'insomnie à l'aide des compositions de l'invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)