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1. (WO2009060292) SMAC MIMETIC COMPOUNDS AS APOPTOSIS INDUCERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/060292    International Application No.:    PCT/IB2008/002971
Publication Date: 14.05.2009 International Filing Date: 05.11.2008
IPC:
C07D 487/04 (2006.01), A61K 31/5517 (2006.01), A61P 35/00 (2006.01)
Applicants: UNIVERSITA'DEGLI STUDI DI MILANO [IT/IT]; Via Festa del Perdono, 7, I-20122 Milano (MI) (IT) (For All Designated States Except US).
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI [IT/IT]; Via Venezian, 1, I-20133 Milan (IT) (For All Designated States Except US).
SCOLASTICO, Carlo [IT/IT]; (IT) (For US Only).
MANZONI, Leonardo, Pierpaolo [IT/IT]; (IT) (For US Only).
SENECI, Pierfausto [IT/IT]; (IT) (For US Only).
BELVISI, Laura [IT/IT]; (IT) (For US Only).
DELIA, Domenico [IT/IT]; (IT) (For US Only).
BOLOGNESI, Martino [IT/IT]; (IT) (For US Only).
MASTRANGELO, Eloise [IT/IT]; (IT) (For US Only).
MILANI, Mario De Mayo De Mari [IT/IT]; (IT) (For US Only).
MOTTO, Llaria [IT/IT]; (IT) (For US Only).
DRAGO, Carmelo [IT/IT]; (IT) (For US Only)
Inventors: SCOLASTICO, Carlo; (IT).
MANZONI, Leonardo, Pierpaolo; (IT).
SENECI, Pierfausto; (IT).
BELVISI, Laura; (IT).
DELIA, Domenico; (IT).
BOLOGNESI, Martino; (IT).
MASTRANGELO, Eloise; (IT).
MILANI, Mario De Mayo De Mari; (IT).
MOTTO, Llaria; (IT).
DRAGO, Carmelo; (IT)
Agent: SANTORO, Tiziana; Marietti, Gislon e Trupiano S.r.l., Via Larga, 16, I-20122 Milano (IT)
Priority Data:
07021843.3 09.11.2007 EP
Title (EN) SMAC MIMETIC COMPOUNDS AS APOPTOSIS INDUCERS
(FR) NOUVEAUX COMPOSÉS MIMÉTIQUES DE SMAC EN TANT QU'INDUCTEURS DE L'APOPTOSE
Abstract: front page image
(EN)The present invention relates to compounds conformationally constrained mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients.
(FR)La présente invention porte sur des composés qui sont des mimétiques contraints, du point de vue de la conformation, de Smac, lesquels agissent en tant qu'inhibiteurs de l'inhibiteur de protéines de l'apoptose (IAP). L'invention porte également sur l'utilisation de ces composés dans une thérapie où l'induction de la mort cellulaire apoptotique est utile, notamment dans le traitement du cancer, individuellement ou en combinaison avec d'autres ingrédients actifs.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)