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1. (WO2009060217) STREPTOCOCCUS PYOGENES CLASSIFICATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/060217    International Application No.:    PCT/GB2008/003769
Publication Date: 14.05.2009 International Filing Date: 06.11.2008
IPC:
C12Q 1/68 (2006.01)
Applicants: NOVARTIS AG [CH/CH]; Lichtstrasse 35 CH-4056 Basel (CH) (For All Designated States Except US).
GRANDI, Guido [IT/IT]; (IT) (For US Only).
MORA, Marirosa [IT/IT]; (IT) (For US Only).
TELFORD, John, L. [GB/IT]; (IT) (For US Only).
ZINGARETTI, Chiara [IT/IT]; (IT) (For US Only).
FALUGI, Fabiana [IT/IT]; (IT) (For US Only)
Inventors: GRANDI, Guido; (IT).
MORA, Marirosa; (IT).
TELFORD, John, L.; (IT).
ZINGARETTI, Chiara; (IT).
FALUGI, Fabiana; (IT)
Agent: BULLETT, Rachel, Margaret; Carpmaels & Ransford 43-45 Bloomsbury Square London WC1A 2RA (GB)
Priority Data:
0721757.3 06.11.2007 GB
Title (EN) STREPTOCOCCUS PYOGENES CLASSIFICATION
(FR) CLASSIFICATION DE STREPTOCOCCUS PYOGENES
Abstract: front page image
(EN)The different Lancefield T-serotypes correlate with the sequence of the pilus backbone protein (Pbp) in Streptococcus pyogenes (GAS). We have sequenced Pbp for over 50 GAS strains, representing the major disease associated serotypes, and have identified 15 Pbp variants. These 15 variants have been shown to determine the specificity of the T-serotyping, such that sequencing of the Pbp from a given GAS strain reliably predicts that strain's T-serotype. Thus the invention permits the T-serotype of a GAS strain to be determined based on genotype.
(FR)Les divers sérotypes T de Lancefield sont corrélés à la séquence de la protéine de squelette de pilus (Pbp) dans Streptococcus pyogenes (GAS). Nous avons séquencé Pbp pour un nombre supérieur à 50 souches de GAS, représentant les principaux sérotypes associés à la maladie, et identifié 15 variantes de Pbp. Ces 15 variantes se sont avérées déterminer la spécificité du sérotypage T, de sorte que le séquençage de ce Pbp à partir d'une souche donnée de GAS prédit avec fiabilité le sérotype T de cette souche. De ce fait, l'invention permet de déterminer le sérotype T d'une souche de GAS en fonction du génotype.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)