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Pub. No.:    WO/2009/060208    International Application No.:    PCT/GB2008/003757
Publication Date: 14.05.2009 International Filing Date: 07.11.2008
C07D 243/12 (2006.01), C07D 403/14 (2006.01)
Applicants: SPIROGEN LIMITED [GB/GB]; 79 George Street, Ryde Isle Of Wight PO33 2JF (GB) (For All Designated States Except US).
HOWARD, Philip [GB/GB]; (GB) (For US Only).
MASTERSON, Luke [GB/GB]; (GB) (For US Only).
ROFFEY, John [GB/GB]; (GB) (For US Only)
Inventors: HOWARD, Philip; (GB).
ROFFEY, John; (GB)
Agent: WATSON, Robert; Mewburn Ellis LLP, 33 Gutter Lane, London EC2V 8AS (GB)
Priority Data:
0722088.2 09.11.2007 GB
Abstract: front page image
(EN)A compound of formula I: wherein: the dotted line indicates the optional presence of a double bond between C2 and C3; R2 is selected from -H, -OH, =O, =CH2, -CN, -R, OR, halo, =CH-R, O-SO2-R, CO2R and COR; R7 is selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR', nitro, Me3Sn and halo; where R and R' are independently selected from optionally substituted C1-7 alkyl, C3-20 heterocyclyl and C5-20 aryl groups; R10 and R11 either together form a double bond, or are selected from H and YRY, where Y is selected from O, S and NH and RY is H or C1-7 alkyl or H and SOxM, where x is 2 or 3, and M is a monovalent pharmaceutically acceptable cation; each X is independently a C5-6 heteroarylene group; n is from 1 to 6.
(FR)L'invention concerne un composé représenté par la formule I dans laquelle la ligne en pointillé indique la présence optionnelle d'une liaison double entre C2 et C3; R2 est sélectionné parmi -H, -OH, =O, =CH2, -CN, -R, OR, halo, =CH-R, O-SO2-R, CO2R et COR; R7 est sélectionné parmi H, R, OH, OR, SH, SR, NH2, NHR, NRR', nitro, Me3Sn et halo; R et R' sont indépendamment sélectionnés parmi des groupes alkyle C1-7, hétérocyclyle C3-20 et aryle C5-20 éventuellement substitués; R10 et R11 forment ensemble une liaison double ou sont sélectionnés parmi H et YRY, Y étant sélectionné parmi O, S et NH et RY étant H ou alkyle C1-7 ou H et SOxM, x étant 2 ou 3, et M étant un cation monovalent pharmaceutiquement acceptable; chaque X est indépendamment un groupe hétéroarylène C5-6; et n varie entre 1 et 6.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)