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Machine translation
1. (WO2009060158) 4- (4-CYANOPHENYL) -1- (3-TRIFLUOROMETHYLPHENYL) -3,4, 6, 7-TETRAHYDRO-1H-PYRROLO [3, 4- D] PYRIMIDINE-2, 5-DIONE DERIVATIVES AND THEIR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/060158    International Application No.:    PCT/GB2007/004238
Publication Date: 14.05.2009 International Filing Date: 07.11.2007
IPC:
C07D 487/04 (2006.01), C07D 519/00 (2006.01), A61K 31/519 (2006.01)
Applicants: ARGENTA DISCOVERY LIMITED [GB/GB]; 8/9 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR (GB) (For All Designated States Except US).
RAY, Nicholas, Charles [GB/GB]; (GB) (For US Only).
FINCH, Harry [GB/GB]; (GB) (For US Only).
EDWARDS, Christine [GB/GB]; (GB) (For US Only).
O'CONNOR, Elizabeth [GB/GB]; (GB) (For US Only).
KULAGOWSKI, Janusz [GB/GB]; (GB) (For US Only)
Inventors: RAY, Nicholas, Charles; (GB).
FINCH, Harry; (GB).
EDWARDS, Christine; (GB).
O'CONNOR, Elizabeth; (GB).
KULAGOWSKI, Janusz; (GB)
Agent: GILL JENNINGS & EVERY LLP; Broadgate House, 7 Eldon Street, London EC2M 7LH (GB)
Priority Data:
Title (EN) 4- (4-CYANOPHENYL) -1- (3-TRIFLUOROMETHYLPHENYL) -3,4, 6, 7-TETRAHYDRO-1H-PYRROLO [3, 4- D] PYRIMIDINE-2, 5-DIONE DERIVATIVES AND THEIR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS
(FR) DÉRIVÉS DE 4-(4-CYANOPHÉNYL)-1-(3-TRIFLUOROMÉTHYLPHÉNYL)-3,4,6,7-TÉTRAHYDRO-1H-PYRROLO[3,4-D]PYRIMIDINE-2,5-DIONE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE L'ÉLASTASE DES NEUTROPHILES HUMAINS
Abstract: front page image
(EN)Thirty six specific compounds having human neutrophil elastase inhibitory activity are disclosed, one of which has the structural formula (1). The compounds are useful inter alia for the treatment of inflammatory respiratory disease, and may be administered by inhalation.
(FR)La présente invention concerne trente-six composés spécifiques possédant une activité inhibitrice de l'élastase des neutrophiles humains, dont l'un a la formule structurale (1). Les composés sont utiles, entre autres, pour le traitement de maladies respiratoires inflammatoires et ils peuvent être administrés par inhalation.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)