WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2009060129) HUMAN MONOCLONAL ANTIBODIES DIRECTED TO SIALYL LEWIS C, SIALYL TN AND N-GLYCOLYLNEURAMINIC ACID EPITOPES AND A METHOD OF ANALYSIS OF STEM CELLS COMPRISING SAID EPITOPES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/060129    International Application No.:    PCT/FI2008/050643
Publication Date: 14.05.2009 International Filing Date: 10.11.2008
Chapter 2 Demand Filed:    07.09.2009    
IPC:
C07K 16/28 (2006.01), C12N 15/13 (2006.01), C12P 21/08 (2006.01), C40B 30/04 (2006.01), G01N 33/532 (2006.01), G01N 33/563 (2006.01), G01N 33/577 (2006.01), C12N 5/08 (2006.01), C12N 7/01 (2006.01)
Applicants: SUOMEN PUNAINEN RISTI, VERIPALVELU [FI/FI]; Kivihaantie 7 FI-00310 Helsinki (FI) (For All Designated States Except US).
GLYKOS FINLAND OY [FI/FI]; Viikinkaari 6, FI-00790 Helsinki (FI) (For All Designated States Except US).
LAUKKANEN, Marja-Leena [FI/FI]; (FI) (For US Only).
TAKKINEN, Kristiina [FI/FI]; (FI) (For US Only).
NATUNEN, Jari [FI/FI]; (FI) (For US Only).
SATOMAA, Tero [FI/FI]; (FI) (For US Only).
PARKKINEN, Jaakko [FI/FI]; (FI) (For US Only).
VALMU, Leena [FI/FI]; (FI) (For US Only).
TIITINEN, Sari [FI/FI]; (FI) (For US Only).
NATUNEN, Suvi [FI/FI]; (FI) (For US Only)
Inventors: LAUKKANEN, Marja-Leena; (FI).
TAKKINEN, Kristiina; (FI).
NATUNEN, Jari; (FI).
SATOMAA, Tero; (FI).
PARKKINEN, Jaakko; (FI).
VALMU, Leena; (FI).
TIITINEN, Sari; (FI).
NATUNEN, Suvi; (FI)
Agent: OY JALO ANT-WUORINEN AB; Iso Roobertinkatu 4-6 A FI-00120 Helsinki (FI)
Priority Data:
20070853 09.11.2007 FI
Title (EN) HUMAN MONOCLONAL ANTIBODIES DIRECTED TO SIALYL LEWIS C, SIALYL TN AND N-GLYCOLYLNEURAMINIC ACID EPITOPES AND A METHOD OF ANALYSIS OF STEM CELLS COMPRISING SAID EPITOPES
(FR) ANTICORPS MONOCLONAUX HUMAINS DIRIGES CONTRE DES EPITOPES DE SIALYLE LEWIS C, DE SIALYLE TN ET D'ACIDE N-GLYCOLYLNEURAMINIQUE ET METHODE D'ANALYSE DE CELLULES SOUCHES CONTENANT CES EPITOPES
Abstract: front page image
(EN)This invention relates to antibody engineering technology. More particularly, the present invention relates to human IgM antibodies and derivatives thereof, which have novel binding specificity with regard to several oligosaccharide sequences and/or xenoantigenic sialic aicd residue. The present invention also relates to processes for making and engineering such novel saccharide and/or NeuGc-binding monoclonal antibodies and to methods for using these antibodies and derivatives thereof in the field of immunodiagnostics, enabling qualitative and quantitative determination of xenoantigenic NeuGc in biological and raw material samples, as well as in immunotherapy, enabling blocking of xenoantigenic NeuGc in patients.
(FR)L'invention concerne une technologie d'ingénierie d'anticorps. L'invention concerne plus particulièrement des anticorps IgM humains et leurs dérivés, qui présentent une nouvelle spécificité de liaison par rapport à plusieurs séquences d'oligosaccharides et/ou un résidu d'acide sialique xénoantigénique. L'invention concerne également des procédés de fabrication et d'ingénierie de ces nouveaux anticorps monoclonaux se liant à NeuGc et/ou à des saccharides, ainsi que des méthodes d'utilisation de ces anticorps et de leurs dérivés dans le diagnostic immunologique, de manière à détecter de façon qualitative et quantitative NeuGc xénoantigénique dans des échantillons biologiques et de matière première, ainsi que dans l'immunothérapie, de manière à bloquer NeuGc xénoantigénique chez des patients.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)