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1. (WO2009059893) CRYSTALLINE HYDRATE OF BETAMIMETIKA AND USE AS MEDICAMENT THEREOF

Pub. No.:    WO/2009/059893    International Application No.:    PCT/EP2008/064201
Publication Date: Fri May 15 01:59:59 CEST 2009 International Filing Date: Wed Oct 22 01:59:59 CEST 2008
IPC: C07D 265/36
A61K 31/538
A61P 11/00
Applicants: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG
AVEN, Michael
SIEGER, Peter
Inventors: AVEN, Michael
SIEGER, Peter
Title: CRYSTALLINE HYDRATE OF BETAMIMETIKA AND USE AS MEDICAMENT THEREOF
Abstract:
The present invention relates to a crystalline, enantiomerically pure hydrate of R-6-hydroxy-8-{1-hydroxy-2-[2-(4-methoxy-phenyI)-1,1-dimethyl-ethylamino]-ethyl}-4H-benzo[1,4]oxazin-3-one-hydrochloride of formula (1) and its activity as a long-acting betamimetic, on its own or combined with one or more other active substances for treating respiratory complaints.