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1. (WO2009059448) STYRENE-ACID DERIVATIVE AND USE IN MANUFACTURING BLOOD-VESSEL TARGETED-AGENT DRUGS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/059448    International Application No.:    PCT/CN2007/003127
Publication Date: 14.05.2009 International Filing Date: 05.11.2007
IPC:
C07C 57/42 (2006.01), C07C 69/618 (2006.01), C07C 211/43 (2006.01), A61K 31/192 (2006.01), A61K 31/196 (2006.01), A61K 31/216 (2006.01), A61P 35/00 (2006.01), A61P 27/02 (2006.01)
Applicants: YONG, Zhiquan [CN/CN]; (CN).
XU, Xiaoping [CN/CN]; (CN)
Inventors: YONG, Zhiquan; (CN).
XU, Xiaoping; (CN)
Agent: LECOME INTELLECTUAL PROPERTY AGENT LTD.; Fl.16, Tower B, INDO Mansion No.48-Jia Zhichun Road Haidian District Beijing 100098 (CN)
Priority Data:
Title (EN) STYRENE-ACID DERIVATIVE AND USE IN MANUFACTURING BLOOD-VESSEL TARGETED-AGENT DRUGS
(FR) DÉRIVÉ STYRÈNE-ACIDE ET UTILISATION DANS LA FABRICATION DE MÉDICAMENTS DE TYPE AGENT CIBLÉ SUR LES VAISSEAUX SANGUINS
(ZH) 苯乙烯酸衍生物及其在制备血管靶向剂药物中的应用
Abstract: front page image
(EN)Styrene-acid derivative of formula (IV) wherein R1, R2, R3, R4 or R5 is H, alkyl, OH, alkoxyl, amidocyanogen, F, Cl, or Br; R11 is Na, K, Li, Mg, Ca, ammonia, carboxy- contained organic amine including amino-acid or peptide, glyceryl, alkoxy, glycosyl containing glucose, multi-hydroxy naphthenic acid containing kinic acid. The compound used in manufacturing blood-vessel targeted-agent drugs, such as anti- tumor drugs and drugs to inhibit angiogenesis of ocular fundus etc.
(FR)La présente invention a pour objet un dérivé styrène-acide de formule (IV) dans laquelle R1, R2, R3, R4 ou R5 est H, un alkyle, OH, un alcoxyle, un amidocyanogène, F, Cl, ou Br ; R11 est Na, K, Li, Mg, Ca, l'ammoniaque, une amine organique contenue dans un carboxy et comprenant un acide aminé ou un peptide, un glycéryle, un alcoxy, un glycosyle contenant un glucose, un acide naphténique multi-hydroxylé contenant de l'acide quinique. Le composé est utilisé dans la fabrication de médicaments de type agent ciblé sur les vaisseaux sanguins, tels que les médicaments antitumoraux et les médicaments pour inhiber l'angiogenèse du fond de l'œil etc.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)