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1. (WO2009059425) STAT3 INHIBITORS FOR THE TREATMENT OF FIBROSIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/059425    International Application No.:    PCT/CA2008/001971
Publication Date: 14.05.2009 International Filing Date: 07.11.2008
IPC:
A61K 31/575 (2006.01), A61K 31/122 (2006.01), A61K 31/202 (2006.01), A61K 31/381 (2006.01), A61K 31/42 (2006.01), A61K 31/7105 (2006.01), A61K 38/17 (2006.01), A61K 45/00 (2006.01), A61K 47/48 (2006.01), A61K 48/00 (2006.01), A61K 9/72 (2006.01), A61P 11/00 (2006.01), C12Q 1/02 (2006.01), A61K 9/00 (2006.01)
Applicants: THE UNIVERSITY OF BRITISH COLUMBIA [CA/CA]; University - Industry Liaison Office, #103 - 6190 Agronomy Road, Vancouver, British Columbia V6T 1Z3 (CA) (For All Designated States Except US).
UNIVERSITY OF WESTERN AUSTRALIA [AU/AU]; 35 Stirling Highway, Crawley, Western Australia 6009 (AU) (For All Designated States Except US).
LUDWIG INSTITUTE FOR CANCER RESEARCH LTD [US/US]; 605 Third Avenue, New York, New York 10158 (US) (For All Designated States Except US).
KNIGHT, Darryl Andrew [AU/CA]; (CA) (For US Only).
MUTSAERS, Steven Eugene [AU/AU]; (AU) (For US Only).
O'DONOGHUE, Robert Joseph James [AU/AU]; (AU) (For US Only).
ERNST, Matthias Rober Walter [CH/AU]; (AU) (For US Only)
Inventors: KNIGHT, Darryl Andrew; (CA).
MUTSAERS, Steven Eugene; (AU).
O'DONOGHUE, Robert Joseph James; (AU).
ERNST, Matthias Rober Walter; (AU)
Agent: MACINS, Andris D.; Smart & Biggar, Box 11560, Vancouver Centre, 2200-650 West Georgia Street, Vancouver, British Columbia V6B 4N8 (CA)
Priority Data:
60/996,235 07.11.2007 US
Title (EN) STAT3 INHIBITORS FOR THE TREATMENT OF FIBROSIS
(FR) INHIBITEURS DE STAT3 DANS LE TRAITEMENT DE LA FIBROSE
Abstract: front page image
(EN)A method of medical treatment or prevention of an interstitial lung disease (ILD) in a subject in need thereof, the method including administering a therapeutically effective amount of a signal transducer and activator of transcription 3 (STAT3) inhibitor to the subject is provided. In other aspects uses of STAT3 inhibitors for treatment and/or prevention of an ILD, or for preparation of medicaments for treatment or prevention of an ILD are provided. The method or use may further include coupling the STAT3 inhibitor to a targeting moiety.
(FR)L'invention porte sur un procédé de traitement médical qui permet de prévenir la maladie du parenchyme pulmonaire chez un sujet qui en a besoin, lequel procédé consiste à administrer une quantité thérapeutiquement efficace d'un transducteur de signal et d'un inhibiteur de l'activateur de transcription 3 (STAT3) à un sujet. Dans d'autres aspects, l'invention fait appel à des inhibiteurs de STAT3 dans le traitement et/ou la prévention de la maladie du parenchyme pulmonaire, ou dans la préparation de médicaments destinés au traitement ou à la prévention de la maladie du parenchyme pulmonaire. On peut également, selon le procédé de l'invention, coupler l'inhibiteur de STAT3 à un fragment de ciblage.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)