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1. (WO2009059414) MITOCHONDRIAL DNA DELETION BETWEEN ABOUT RESIDUES 12317-16254 FOR USE IN THE DETECTION OF CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/059414    International Application No.:    PCT/CA2008/001956
Publication Date: 14.05.2009 International Filing Date: 10.11.2008
IPC:
C12Q 1/68 (2006.01), C12P 19/34 (2006.01), C12N 15/11 (2006.01)
Applicants: GENESIS GENOMICS INC. [CA/CA]; Suite 1000, 290 Munro Street, Thunder Bay, Ontario P7A 7T1 (CA) (For All Designated States Except US).
PARR, Ryan [CA/CA]; (CA) (For US Only).
CREED, Jennifer [CA/CA]; (CA) (For US Only).
ROBINSON, Kerry [CA/CA]; (CA) (For US Only).
MAGGRAH, Andrea [CA/CA]; (CA) (For US Only).
MAKI, Katrina [CA/CA]; (CA) (For US Only).
DAKUBO, Gabriel [CA/CA]; (CA) (For US Only).
REGULY, Brian [CA/CA]; (CA) (For US Only).
HARBOTTLE, Andrew [GB/GB]; (GB) (For US Only).
ALEXANDER, Jude [CA/CA]; (CA) (For US Only)
Inventors: PARR, Ryan; (CA).
CREED, Jennifer; (CA).
ROBINSON, Kerry; (CA).
MAGGRAH, Andrea; (CA).
MAKI, Katrina; (CA).
DAKUBO, Gabriel; (CA).
REGULY, Brian; (CA).
HARBOTTLE, Andrew; (GB).
ALEXANDER, Jude; (CA)
Agent: CHARI, Santosh, K.; Blake, Cassels & Graydon LLP, Box 25, Commerce Court West, 199 Bay Street, Suite 2800, Toronto, Ontario M5L 1A9 (CA)
Priority Data:
61/002,637 09.11.2007 US
Title (EN) MITOCHONDRIAL DNA DELETION BETWEEN ABOUT RESIDUES 12317-16254 FOR USE IN THE DETECTION OF CANCER
(FR) SUPPRESSION DE MUTATIONS D'ADN MITOCHONDRIAL ENTRE LES RÉSIDUS 12317-16254 POUR UNE UTILISATION DANS LA DÉTECTION D'UN CANCER
Abstract: front page image
(EN)The present invention relates to methods for predicting, diagnosing and monitoring cancer. The methods comprise obtaining biological samples, extracting mitochondrial DNA (mtDNA) from the samples, quantifying a mtDNA mutation in the sample and comparing the level of the mtDNA mutation present in the sample with a reference value The methods of the invention may also be effective in screening for new therapeutic agents and treatment regimes Further, said methods may be also be useful for monitoring the response of a subject to a preventative or therapeutic treatment.
(FR)La présente invention concerne des procédés pour prédire, diagnostiquer et surveiller un cancer. Les procédés comportent l'obtention d'échantillons biologiques, l'extraction d'ADN mitochondrial (ADNmt) des échantillons, la quantification d'une mutation d'ADN mitochondrial dans l'échantillon et la comparaison du niveau de mutation d'ADNmt avec une valeur de référence. Les procédés de l'invention peuvent également être efficaces dans le criblage de nouveaux agents thérapeutiques et de régimes de traitement, et peuvent aussi s'utiliser pour surveiller la réponse d'un sujet à un traitement préventif ou thérapeutique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)