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1. (WO2009059309) FURIN-CLEAVABLE PEPTIDE LINKERS FOR DRUG-LIGAND CONJUGATES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/059309    International Application No.:    PCT/US2008/082270
Publication Date: 07.05.2009 International Filing Date: 03.11.2008
IPC:
A61K 47/48 (2006.01), A61K 38/02 (2006.01), A61P 35/00 (2006.01)
Applicants: PANACEA PHARMACEUTICALS, INC. [US/US]; 207 Perry Parkway, Suite 2 Gaithersburg, MD 20877 (US) (For All Designated States Except US).
ROBERTS, Steve [US/US]; (US) (For US Only).
LEBOWITZ, Michael, S. [US/US]; (US) (For US Only).
GHANBARI, Hossein, A. [US/US]; (US) (For US Only)
Inventors: ROBERTS, Steve; (US).
LEBOWITZ, Michael, S.; (US).
GHANBARI, Hossein, A.; (US)
Priority Data:
60/984,562 01.11.2007 US
Title (EN) FURIN-CLEAVABLE PEPTIDE LINKERS FOR DRUG-LIGAND CONJUGATES
(FR) LIEURS DE PEPTIDE CLIVABLES PAR FURINE POUR DES CONJUGUÉS MÉDICAMENT-LIGAND
Abstract: front page image
(EN)Disclosed are certain peptide linkers for conjugating drugs to ligands, and the resulting drug-linker-ligand molecules and compositions thereof. The conjugated molecules useful for the targeted delivery of drugs to the desired cells, and allow for the intracellular release of the drug in cases where the targeted antigen is internalized via the trans Golgi network and not the lysosomal pathway.
(FR)L'invention concerne certains lieurs de peptide pour conjuguer des médicaments à des ligands, et les molécules de médicament-lieur-ligand résultantes et leurs compositions. Les molécules conjuguées sont utiles pour l'administration ciblée de médicaments aux cellules souhaitées, et permettent la libération intracellulaire de médicament dans le cas où l'antigène ciblé est internalisé via le réseau trans Golgi et non la voie lysosomale.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)