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1. (WO2009059259) DETECTION OF WORSENING RENAL DISEASE IN SUBJECTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/059259    International Application No.:    PCT/US2008/082166
Publication Date: 07.05.2009 International Filing Date: 31.10.2008
IPC:
C12Q 1/68 (2006.01), G01N 33/53 (2006.01)
Applicants: CHILDREN'S HOSPITAL MEDICAL CENTER [US/US]; 3333 Burnet Avenue, Cincinnati, OH 45229 (US) (For All Designated States Except US).
BRUNNER, Hermine, I. [DE/US]; (US).
DEVARAJAN, Prasad [US/US]; (US) (For US Only)
Inventors: BRUNNER, Hermine, I.; (US).
DEVARAJAN, Prasad; (US)
Agent: RICHTER, Ronald, J.; Hasse & Nesbitt LLC, 8837 Chapel Square Drive, Suite C, Cincinnati, OH 45249 (US)
Priority Data:
60/984,233 31.10.2007 US
Title (EN) DETECTION OF WORSENING RENAL DISEASE IN SUBJECTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
(FR) DÉTECTION DE L'AGGRAVATION D'UNE PATHOLOGIE RÉNALE CHEZ DES SUJETS ATTEINTS DE LUPUS ÉRYTHÉMATEUX DISSÉMINÉ
Abstract: front page image
(EN)Methods for the detection active lupus nephritis (LN) and worsening renal disease activity and/or active LN in patients diagnosed with systemic lupus erythematosus, using a panel of biomarkers including urinary neutrophil gelatinase associated lipocalin (UNGAL), transferrin (Tf), ceruloplasmin (Cp), lipocalin-like prostaglandin D synthetase (L-PGDS), and alpha- 1 -acid glycoprotein (AGPl).
(FR)L'invention concerne des procédés de détection d'une néphrite lupique (NL) active et de l'aggravation de l'activité d'une maladie rénale et/ou d'une NL active chez des patients atteints de lupus érythémateux disséminé, en utilisant un panel de biomarqueurs comprenant la lipocaline neutrophile associée à la gélatinase urinaire (UNGAL), la transferrine (Tf), la céruloplasmine (Cp), la prostaglandine D synthétase analogue à la lipocaline (L-PGDS), et l'alpha-1 glycoprotéine acide (AGP1).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)