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1. (WO2009059195) RATIONALLY-DESIGNED SINGLE-CHAIN MEGANUCLEASES WITH NON-PALINDROMIC RECOGNITION SEQUENCES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/059195    International Application No.:    PCT/US2008/082072
Publication Date: 07.05.2009 International Filing Date: 31.10.2008
IPC:
C12N 9/22 (2006.01)
Applicants: PRECISION BIOSCIENCES, INC. [--/US]; 104 T.W. Alexander Drive, Bldg. 7 Research Triangle Park, NC 27709 (US) (For All Designated States Except US).
SMITH, James, Jefferson [US/US]; (US) (For US Only).
JANTZ, Derek [US/US]; (US) (For US Only)
Inventors: SMITH, James, Jefferson; (US).
JANTZ, Derek; (US)
Agent: TWOMEY, Michael, J.; Wilmer Cutler Pickering Hale And Dorr LLP 60 State Street Boston, MA 02109 (US)
Priority Data:
61/001,247 31.10.2007 US
Title (EN) RATIONALLY-DESIGNED SINGLE-CHAIN MEGANUCLEASES WITH NON-PALINDROMIC RECOGNITION SEQUENCES
(FR) MÉGANUCLÉASES MONOCATÉNAIRES CONÇUES RATIONNELLEMENT CONTENANT DES SÉQUENCES DE RECONNAISSANCE NON PALINDROMIQUES
Abstract: front page image
(EN)Disclosed are rationally-designed, non-naturally-occurring meganucleases in which a pair of enzyme subunits having specificity for different recognition sequence half-sites are joined into a single polypeptide to form a functional heterodimer with a non- palindromic recognition sequence. The invention also relates to methods of producing such meganucleases, and methods of producing recombinant nucleic acids and organisms using such meganucleases.
(FR)L'invention concerne des méganucléases non présentes dans la nature, conçues de manière rationnelle, dans lesquelles une paire de sous-unités enzymatiques présentant une spécificité pour différents demi-sites de séquences de reconnaissance est assemblée en un polypeptide unique afin de former un hétérodimère fonctionnel avec une séquence de reconnaissance non palindromique. L'invention concerne également des procédés de production de ces méganucléases, ainsi que des procédés de production d'acides nucléiques et d'organismes recombinants en utilisant ces méganucléases.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)