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1. (WO2009059107) SYNTHESIS OF RING B ABEO-STEROLS AS NOVEL INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/059107    International Application No.:    PCT/US2008/081956
Publication Date: 07.05.2009 International Filing Date: 31.10.2008
IPC:
A61K 51/00 (2006.01)
Applicants: OFFICE OF INTELLECTUAL PROPERTY AND TECHNOLOGY VICE PRESIDENCY FOR RESEARCH AND TECHNOLOGY [US/US]; University of Puerto Rico, Botanical Garden South, 1187 Flamboyan Street, San Juan, PR 00926-1117 (US) (For All Designated States Except US).
RODRIGUEZ-PIERLUISSI, Abimael, D. [US/US]; (US).
WEI, Xiaomei [CN/US]; (US)
Inventors: RODRIGUEZ-PIERLUISSI, Abimael, D.; (US).
WEI, Xiaomei; (US)
Agent: RIOS, Roberto; Hoglund & Pamias, P.S.C., 256 Eleanor Roosevelt, San Juan, PR 00918 (US)
Priority Data:
60/983,990 31.10.2007 US
Title (EN) SYNTHESIS OF RING B ABEO-STEROLS AS NOVEL INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS
(FR) SYNTHÈSE D'ABÉO-STÉROLS DE CYCLE B EN TANT QUE NOUVEAUX INHIBITEURS DE LA TUBERCULOSE MYCOBACTÉRIENNE
Abstract: front page image
(EN)Novel 3β-hydroxy-Δ5-steroid analogs possessing a contracted cyclopentane B-ring provide good inhibitory activity against Mycobacterium tuberculosis. The 5(6→7)abeo-sterol nucleus present in compounds of the invention represents a novel scaffold for the development of new antitubercular agents.
(FR)La présente invention concerne de nouveaux analogues 3β-hydroxy-Δ5-stéroïdes possédant un cycle B de cyclopentane contracté. Ceux-ci fournissent une bonne activité inhibitrice de Mycobacterium tuberculosis. Le noyau abéo-stérol 5(6→7) présent dans les composés de l'invention représente un nouvel échafaudage permettant la mise au point de nouveaux agents antituberculeux.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)