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1. (WO2009058852) MINOR GROOVE BINDER-ENERGY TRANSFER OLIGONUCLEOTIDES AND METHODS FOR THEIR USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/058852    International Application No.:    PCT/US2008/081570
Publication Date: 07.05.2009 International Filing Date: 29.10.2008
IPC:
C07H 21/00 (2006.01)
Applicants: EPOCH BIOSCIENCES, INC. [US/US]; 21720 23rd Drive, SE, #150 Bothell, Washington 98021 (US) (For All Designated States Except US).
LUKHTANOV, Eugene [US/US]; (US) (For US Only).
SCARR, Noah [US/US]; (US) (For US Only).
VOROBIEV, Alexei V. [RU/US]; (US) (For US Only)
Inventors: LUKHTANOV, Eugene; (US).
SCARR, Noah; (US).
VOROBIEV, Alexei V.; (US)
Priority Data:
11/929,884 30.10.2007 US
Title (EN) MINOR GROOVE BINDER-ENERGY TRANSFER OLIGONUCLEOTIDES AND METHODS FOR THEIR USE
(FR) LIGAND DU PETIT SILLON-OLIGONUCLÉOTIDES DESTINÉS AU TRANSFERT D'ÉNERGIE ET PROCÉDÉS POUR LEUR UTILISATION
Abstract: front page image
(EN)The incorporation of a minor groove binder spaced close to one member of a matched FRET set in a minor groove binder-oligonucleotide conjugate significantly reduces background fluorescence of a FRET probe or pair of probes and, consequently, increases the S/B ratios. Fluorescent-labeled probes are useful in carrying out hybridization, multiplex nucleic acid detection, and other procedures.
(FR)L'incorporation d'un ligand du petit sillon espacé de sorte à être à proximité d'un élément d'un ensemble FRET correspondant dans un conjugué ligand du petit sillon-oligonucléotide réduit de manière significative la fluorescence de fond d'une sonde ou d'une paire de sondes FRET et, par conséquent, augmente les rapports S/B. Les sondes marquées par fluorescence sont utiles pour effectuer une hybridation, une détection multiplexée d'acides nucléiques, et d'autres procédures.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)