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1. (WO2009058661) USE AND PRODUCTION OF CITRATE-STABLE NEUTRAL METALLOPROTEASES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2009/058661 International Application No.: PCT/US2008/080972
Publication Date: 07.05.2009 International Filing Date: 23.10.2008
IPC:
C12N 9/54 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
48
acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
50
Proteinases
52
derived from bacteria
54
bacteria being Bacillus
Applicants:
DANISCO US INC. [US/US]; 925 Page Mill Road Palo Alto, California 94304, US (AllExceptUS)
HOMMES, Ronaldus, W. J. [NL/NL]; US (UsOnly)
LIU, Amy [CA/US]; US (UsOnly)
SHAW, Andrew [US/US]; US (UsOnly)
WALLACE, Louise [ZA/US]; US (UsOnly)
Inventors:
HOMMES, Ronaldus, W. J.; US
LIU, Amy; US
SHAW, Andrew; US
WALLACE, Louise; US
Agent:
MACKNIGHT, Kamrin, T.; Danisco Us Inc., Genencor Division 925 Page Mill Road Palo Alto, California 94304, US
Priority Data:
60/984,04631.10.2007US
Title (EN) USE AND PRODUCTION OF CITRATE-STABLE NEUTRAL METALLOPROTEASES
(FR) UTILISATION ET PRODUCTION DE MÉTALLOPROTÉASES NEUTRES STABLES VIS-À-VIS DES CITRATES
Abstract:
(EN) The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme that has improved stability in the presence of a metal chelator. In some embodiments, the neutral metalloprotease finds use in cleaning and other applications comprising citrate. In some particularly preferred embodiments, the present invention provides methods and compositions comprising variant neutral metalloprotease(s) engineered to resist citrate-induced autolysis.
(FR) La présente invention porte sur des procédés et des compositions comprenant au moins une enzyme métalloprotéase neutre qui présente une stabilité améliorée en présence d'un chélateur de métaux. Dans certains modes de réalisation, la métalloprotéase neutre trouve une utilisation dans des applications de nettoyage et autres applications comprenant du citrate. Dans certains modes de réalisation particulièrement privilégiés, la présente invention porte sur des procédés et des compositions comprenant une ou des métalloprotéases neutres variantes mises au point pour résister à une autolyse induite par un citrate.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
KR1020100075986EP2205731JP2011502481MXMX/a/2010/004372US20110081454CA2703975
CN101842481DK2205731BRPI0818788IN2069/DELNP/2010