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1. (WO2009058446) RECOMBINANT FACTOR VIII HAVING INCREASED STABILITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/058446    International Application No.:    PCT/US2008/071170
Publication Date: 07.05.2009 International Filing Date: 25.07.2008
IPC:
C12Q 1/68 (2006.01), C12P 21/06 (2006.01), C07K 14/755 (2006.01)
Applicants: UNIVERSITY OF ROCHESTER [US/US]; 601 Elmwood Avenue, Box Ott, Rochester, NY 14642 (US) (For All Designated States Except US).
FAY, Philip, J. [US/US]; (US) (For US Only).
WAKABAYASHI, Hironao [JP/US]; (US) (For US Only)
Inventors: FAY, Philip, J.; (US).
WAKABAYASHI, Hironao; (US)
Agent: MERKEL, Edwin, V.; Nixon Peabody Llp, 1100 Clinton Square, Rochester, NY 14604-1792 (US)
Priority Data:
60/984,518 01.11.2007 US
60/991,304 30.11.2007 US
Title (EN) RECOMBINANT FACTOR VIII HAVING INCREASED STABILITY
(FR) FACTEUR VIII RECOMBINANT AYANT UNE STABILITÉ ACCRUE
Abstract: front page image
(EN)The present invention relates to a recombinant factor VIII that includes one or more mutations that result in enhanced stability of both factor VIII and factor VIIIa. Methods of making and using the recombinant factor VlIl, and pharmaceutical compositions containing the same are also disclosed. The present invention further relates to an isolated nucleic acid molecule that encodes the recombinant factor VIII, as well as DNA expression systems and host cells containing the isolated nucleic acid molecule.
(FR)La présente invention porte sur un facteur VIII recombinant qui comprend une ou plusieurs mutations qui conduisent à une stabilité accrue à la fois du facteur VIII et du facteur VIIIa. L'invention porte également sur des procédés de fabrication et d'utilisation du facteur VIII recombinant et sur des compositions pharmaceutiques contenant ceux-ci. La présente invention porte également sur une molécule d'acide nucléique isolée qui code pour le facteur VIII recombinant, ainsi que sur des systèmes d'expression d'ADN et des cellules hôtes contenant la molécule d'acide nucléique isolée.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)