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1. (WO2009058346) ANTIBODIES TO GDF8 AS USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/058346    International Application No.:    PCT/US2008/012338
Publication Date: 07.05.2009 International Filing Date: 31.10.2008
IPC:
C07K 16/22 (2006.01)
Applicants: WYETH LLC [US/US]; Five Giralda Farms Madison, New Jersey 07940 (US) (For All Designated States Except US).
LAVALLIE, Edward, Roland [US/US]; (US) (For US Only).
COLLINS-RACIE, Lisa Anne [US/US]; (US) (For US Only).
CORCORAN, Christopher, John [US/US]; (US) (For US Only).
TCHISTIAKOVA, Lioudmila, Gennadievna [CA/US]; (US) (For US Only).
NOWAK, John, Adam [US/US]; (US) (For US Only).
KARIM, Riyez [CA/US]; (US) (For US Only).
TAN, Xiang-Yang [US/US]; (US) (For US Only).
MARQUETTE, Kimberly, Ann [US/US]; (US) (For US Only).
VELDMAN, Geertruida, Machteld [US/US]; (US) (For US Only)
Inventors: LAVALLIE, Edward, Roland; (US).
COLLINS-RACIE, Lisa Anne; (US).
CORCORAN, Christopher, John; (US).
TCHISTIAKOVA, Lioudmila, Gennadievna; (US).
NOWAK, John, Adam; (US).
KARIM, Riyez; (US).
TAN, Xiang-Yang; (US).
MARQUETTE, Kimberly, Ann; (US).
VELDMAN, Geertruida, Machteld; (US)
Agent: SULLIVAN, Kelly, M.; Wyeth LLC Patent Law Department Five Giralda Farms Madison, New Jersey 07940 (US)
Priority Data:
61/001,783 01.11.2007 US
Title (EN) ANTIBODIES TO GDF8 AS USES THEREOF
(FR) ANTICORPS DIRIGÉS CONTRE GDF8 ET LEURS UTILISATIONS
Abstract: front page image
(EN)The disclosure provides novel molecules related to growth and differentiation factor 8 (GDF8), in particular epitopes specific to GDF8 and other specific antagonists of GDF8 in particular anti GDF8 antibodies or antigen binding protein or fragment thereof that may inhibit GDF8 activity and signal in vitro and/or in vivo. The disclosure also provides for an immunoassay used to detect and quantitate GDF8. The disclosure also provides methods for diagnosing, preventing, ameliorating, and treating GDF8 associated disorders, e.g., degenerative orders of muscle, bone, and insulin metabolism. Finally, the disclosure provides pharmaceuticals for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
(FR)L'invention porte sur de nouvelles molécules se rapportant au facteur 8 de croissance et de différenciation (GDF8), en particulier aux épitopes spécifiques de GDF8 et autres antagonistes spécifiques de GDF8 en particulier des anticorps anti-GDF8 ou une protéine de liaison à un antigène ou à un fragment de celle-ci qui peuvent inhiber l'activité et le signal de GDF8 in vitro et/ou in vivo. L'invention porte également sur un immunoessai utilisé pour détecter et quantifier GDF8. L'invention porte également sur des procédés de diagnostic, de prévention, d'amélioration et de traitement de troubles associés au GDF8, par exemple les troubles dégénératifs du muscle, de l'os et du métabolisme de l'insuline. Enfin, l'invention porte sur des produits pharmaceutiques pour le traitement de tels troubles à l'aide des anticorps, polypeptides, polynucléotides et vecteurs de l'invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)