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1. (WO2009058203) RADIOLABELED MONOCLONAL ANTIBODIES, METHODS OF PREPARATION USING TCEP, AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2009/058203 International Application No.: PCT/US2008/011956
Publication Date: 07.05.2009 International Filing Date: 21.10.2008
IPC:
C07K 16/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
Applicants:
DADACHOVA, Ekaterina [AU/US]; US (UsOnly)
CASADEVALL, Arturo [US/US]; US (UsOnly)
SESAY, Muctarr, A. [US/US]; US (UsOnly)
DAMANIA, Hema [IN/US]; US (UsOnly)
SMARIGA, Paulette, E. [US/US]; US (UsOnly)
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY [US/US]; 1300 Morris Park Avenue Bronx, NY 10461, US (AllExceptUS)
GOODWIN BIOTECHNOLOGY, INC. [US/US]; 1850 N.W. 69 Avenue Plantation, Florida 33313, US (AllExceptUS)
PAIN THERAPEUTICS, INC. [US/US]; 2211 Bridgepointe Parkway Suite 500 San Mateo, CA 94404, US (AllExceptUS)
Inventors:
DADACHOVA, Ekaterina; US
CASADEVALL, Arturo; US
SESAY, Muctarr, A.; US
DAMANIA, Hema; US
SMARIGA, Paulette, E.; US
Agent:
MILLER, Alan, D. ; AMSTER, ROTHSTEIN & EBENSTEIN LLP 90 Park Avenue New York, New York 10016, US
Priority Data:
61/000,79529.10.2007US
Title (EN) RADIOLABELED MONOCLONAL ANTIBODIES, METHODS OF PREPARATION USING TCEP, AND USES THEREOF
(FR) ANTICORPS MONOCLONAUX MARQUÉS, LEURS PROCÉDÉS DE PRÉPARATION À L'AIDE DE TCEP ET LEURS UTILISATIONS
Abstract:
(EN) This application discloses methods for producing radiolabeled IgM or IgA monoclonal antibodies using tris(2-carboxyethyl) phosphine hydrochloride (TCEP) to reduce disulfide bonds to generate sulfhydryl (-SH) groups and treating the monoclonal antibody with a radioisotope that binds to -SH groups, radiolabeled antibodies produced by the methods, monoclonal anti-melanin IgM antibodies containing about 42 to about 45 -SH groups, and methods of treating and imaging cancer, such an melanoma, and infections using the radiolabeled antibodies.
(FR) Cette invention concerne des procédés de production d'anticorps monoclonaux IgM ou IgA marqués à l'aide de chlorhydrate de tris(2-carboxyéthyl)-phosphine (TCEP) pour réduire les liaisons disulfures pour générer des groupes sulfhydryles (-SH), et de traitement de l'anticorps monoclonal par un radio-isotope qui se lie à des groupes -SH. L'invention concerne également des anticorps marqués obtenus par les procédés, des anticorps monoclonaux IgM anti-mélanine contenant d'environ 42 à 45 groupes -SH et des procédés de traitement et d'imagerie d'un cancer, tel qu'un mélanome, et d'infections à l'aide des anticorps marqués.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)