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1. (WO2009057695) METHOD FOR DETECTION OF ADENOMA OR CANCER BY GENETIC ANALYSIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/057695    International Application No.:    PCT/JP2008/069757
Publication Date: 07.05.2009 International Filing Date: 30.10.2008
Chapter 2 Demand Filed:    01.07.2009    
IPC:
C12Q 1/68 (2006.01), C12N 15/09 (2006.01)
Applicants: OLYMPUS CORPORATION [JP/JP]; 43-2, Hatagaya 2-chome, Shibuya-ku, Tokyo 1510072 (JP) (For All Designated States Except US).
NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE [JP/JP]; 20-1, Handayama 1-chome, Higashi-ku, Hamamatsu-shi Shizuoka 4313192 (JP) (For All Designated States Except US).
AKESAKA, Tamao [JP/JP]; (JP) (For US Only).
NAGAOKA, Tomonori [JP/JP]; (JP) (For US Only).
KANAOKA, Shigeru [JP/JP]; (JP) (For US Only).
YOSHIDA, Kenichi [JP/JP]; (JP) (For US Only)
Inventors: AKESAKA, Tamao; (JP).
NAGAOKA, Tomonori; (JP).
KANAOKA, Shigeru; (JP).
YOSHIDA, Kenichi; (JP)
Agent: TANAI, Sumio; 1-9-2, Marunouchi Chiyoda-ku, Tokyo 100-6620 (JP)
Priority Data:
2007-282044 30.10.2007 JP
2008-222748 29.08.2008 JP
2008-252649 30.09.2008 JP
Title (EN) METHOD FOR DETECTION OF ADENOMA OR CANCER BY GENETIC ANALYSIS
(FR) PROCÉDÉ DE DÉTECTION D'UN ADÉNOME OU D'UN CANCER PAR ANALYSE GÉNÉTIQUE
(JA) 遺伝子解析による腺腫又はがんの検出方法
Abstract: front page image
(EN)Disclosed is a method which enables to detect an adenoma or cancer at an early stage by performing a gene expression analysis on a biological marker in a sample that can be collected readily. Specifically disclosed is a method for detecting an adenoma or cancer, which comprises the steps of: measuring the quantity of a sequence constituting at least one house-keeping gene or an expression product thereof contained in a body fluid sample or an excrement sample collected from a subject; and calculating the concentration of the sequence in the sample.
(FR)L'invention concerne un procédé qui permet de détecter un adénome ou un cancer à un stage précoce en effectuant une analyse d'expression génétique sur un marqueur biologique dans un échantillon qui peut être prélevé facilement. L'invention concerne en particulier un procédé de détection d'un adénome ou d'un cancer, qui comprend les étapes consistant à : mesurer la quantité d'une séquence constituant au moins un gène domestique ou un produit d'expression de celui-ci contenu dans un échantillon de fluide corporel ou d'un échantillon d'excrément prélevé chez un sujet ; et calculer la concentration de la séquence dans l'échantillon.
(JA)本発明においては、容易に採取可能な試料について生物学的マーカーの遺伝子発現解析を行うことにより、腺腫・がんの早期検出を可能にする方法を提供することを課題としている。本発明は、被験者から採取した体液試料又は排泄物試料中に含まれる、少なくとも一のハウスキーピング遺伝子又はその発現産物を構成する配列の量を測定して、試料中の当該配列の濃度を算出する工程を含む、腺腫・がん検出方法を提供する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)