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1. (WO2009057133) A PROCESS FOR THE SYNTHESIS OF 2-[2-[4-[(4-CHLOROPHENYL)PHENYL METHYL]-1-PIPERAZINYL] ETHOXY ACETIC ACID
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/057133    International Application No.:    PCT/IN2008/000419
Publication Date: 07.05.2009 International Filing Date: 03.07.2008
IPC:
C07D 295/14 (2006.01), C07C 235/06 (2006.01)
Applicants: GLENMARK GENERICS LIMITED [IN/IN]; Glenmark House, Hdo-corporate Building, Wing-a, B.d.sawant Marg, Chakala,, Andheri (east), Mumbai, Mumbai 400099 (IN) (For All Designated States Except US).
BADGUJAR, Santosh Ramesh [IN/IN]; (IN) (For US Only).
KAMBLE, Hemant Harishchandra [IN/IN]; (IN) (For US Only).
SHARMA, Vipin [IN/IN]; (IN) (For US Only).
PATEL, Dharmeshkumar Arvindbhai [IN/IN]; (IN) (For US Only).
KHAN, Mubeen Ahmed [IN/IN]; (IN) (For US Only)
Inventors: BADGUJAR, Santosh Ramesh; (IN).
KAMBLE, Hemant Harishchandra; (IN).
SHARMA, Vipin; (IN).
PATEL, Dharmeshkumar Arvindbhai; (IN).
KHAN, Mubeen Ahmed; (IN)
Priority Data:
1428/MUM/2007 24.07.2007 IN
1875/MUM/2007 24.09.2007 IN
Title (EN) A PROCESS FOR THE SYNTHESIS OF 2-[2-[4-[(4-CHLOROPHENYL)PHENYL METHYL]-1-PIPERAZINYL] ETHOXY ACETIC ACID
(FR) PROCÉDÉ DE SYNTHÈSE D'ACIDE 2-[2-[4-[(4-CHLOROPHÉNYL)PHÉNYLMÉTHYL]-1-PIPÉRAZINYL]ÉTHOXY-ACÉTIQUE
Abstract: front page image
(EN)TAbstract A process for the preparation of 2-[2-[4-[(4-chloro phenyl) phenyl methyl]-1-piperazinyl] ethoxy acetic acid of formula (Ia) and pharmaceutically acceptable salts thereof, and compounds of formula (IIa) and (VIIIa), wherein R1 = H or C1-C4 alkyl; R2 = aryl or heteroaryl or R1 and R2 together with the carbon to which they are attached form a C3-C8 cycloalkyl group and X is a suitable leaving group for example, chlorine, bromine, iodine, 4-methylphenyl-sulfonyloxy, methylsulfonyloxy group or 4-bromophenyl-sulfonyloxy group are described.
(FR)L'invention concerne un procédé de préparation d'acide 2-[2-[4-[(4-chlorophényl)phénylméthyl]-1-pipérazinyl]éthoxy-acétique de formule (Ia) et de ses sels pharmaceutiquement acceptables, et de composés de formule (IIa) et (VIIIa), dans lesquelles R1 représente H ou un groupe alkyle en C1-C4; R2 représente un groupe aryle ou hétéroaryle ou R1 et R2 associés à l'atome de carbone auxquels ils sont attachés forment un groupe cycloalkyle en C3-C8 et X représente un groupe labile approprié, par exemple un atome de chlore, de brome, d'iode, un groupe 4-méthylphényl-sulfonyloxy, méthylsulfonyloxy ou 4-bromophényl-sulfonyloxy.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)