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1. (WO2009056881) CHEMICAL COMPOUNDS 313
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/056881    International Application No.:    PCT/GB2008/051012
Publication Date: 07.05.2009 International Filing Date: 29.10.2008
IPC:
C07D 401/04 (2006.01), A61K 31/4427 (2006.01)
Applicants: ASTRAZENECA AB [SE/SE]; S-151 85 Södertälje (SE) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
ASTRAZENECA UK LIMITED [GB/GB]; 15 Stanhope Gate, London Greater London W1K 1LN (GB) (MG only).
MCCOULL, William [GB/GB]; (GB) (For US Only).
PACKER, Martin [GB/GB]; (GB) (For US Only).
SCOTT, James, Stewart [GB/GB]; (GB) (For US Only).
WHITTAMORE, Paul, Robert, Owen [GB/GB]; (GB) (For US Only)
Inventors: MCCOULL, William; (GB).
PACKER, Martin; (GB).
SCOTT, James, Stewart; (GB).
WHITTAMORE, Paul, Robert, Owen; (GB)
Agent: ASTRAZENECA INTELLECTUAL PROPERTY; AstraZeneca AB, S-151 85 Södertälje (SE)
Priority Data:
96140633 29.10.2007 TW
11/928,744 30.10.2007 US
61/048,258 28.04.2008 US
Title (EN) CHEMICAL COMPOUNDS 313
(FR) COMPOSÉS CHIMIQUES 313
Abstract: front page image
(EN)(1R,5S,6r)-3-[5-(Adamantan-2-ylcarbamoyl)-6-(methylthio)pyridin-2-yl]-3- azabicyclo[3.1.0]hexane-6-carboxylic acid and ph armaceutically-acceptable salts thereof; its use in the inhibition of 11β HSD1, processes for making it and pharmaceutical compositions comprising it are also described.
(FR)La présente invention concerne l'acide (1R,5S,6r)-3-[5-(adamantan-2-ylcarbamoyl)-6-(méthylthio)pyridin-2-yl]-3-azabicyclo[3.1.0]hexane-6-carboxylique et ses sels acceptables sur le plan pharmaceutique ; ainsi que son utilisation dans l'inhibition de la 11β-HSD1, ses procédés de fabrication et des compositions pharmaceutiques le renfermant.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)