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1. (WO2009056660) NOVEL CHEMOTHERAPEUTIC AGENTS FOR CANCER TREATMENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/056660    International Application No.:    PCT/ES2008/000671
Publication Date: 07.05.2009 International Filing Date: 29.10.2008
IPC:
C07D 493/18 (2006.01), A61K 31/343 (2006.01), A61P 35/00 (2006.01)
Applicants: UNIVERSIDAD DE BARCELONA [ES/ES]; Centro de Patentes de la UB, Baldiri Reixac, 4, E-08028 Barcelona (ES) (For All Designated States Except US).
MONTAÑA PEDRERO, Ángel Manuel [ES/ES]; (ES) (For US Only).
PONZANO, Stefano [IT/ES]; (ES) (For US Only)
Inventors: MONTAÑA PEDRERO, Ángel Manuel; (ES).
PONZANO, Stefano; (ES)
Agent: SEGURA CÁMARA, Pascual; Centro de Patentes de la UB, C/ Baldiri Reixac, 4, E-08028 Barcelona (ES)
Priority Data:
P200702920 29.10.2007 ES
Title (EN) NOVEL CHEMOTHERAPEUTIC AGENTS FOR CANCER TREATMENT
(ES) NUEVOS AGENTES QUIMIOTERAPÉUTICOS PARA EL TRATAMIENTO DEL CÁNCER
(FR) NOUVEAUX AGENTS CHIMIOTHÉRAPEUTIQUES POUR LE TRAITEMENT DU CANCER
Abstract: front page image
(EN)The invention relates to compounds having formula (15), shown below, in which R1 is H or I, R2 is a radical selected from (C1-C16)-alkyl, phenyl and benzyl, R3 is a (C2-C4)-alkyl group and the configuration of C in substituent (R2O)(R3COO)CH is R or S, which compounds have been shown to be active against a plurality of human cancerous cell lines, in particular against the cell lines of melanoma, leukemia, non-small cell lung cancer, renal cancer, ovarian cancer, colon cancer, CNS cancer, breast cancer and prostate cancer. Consequently, said compounds are promising anticancer agents for the treatment of different types of cancer.
(ES)Los compuestos de fórmula (15) mostrados más abajo, donde R1 es H o I, R2 es un radical seleccionado entre (C1-C16)-alquilo, fenilo, y bencilo, R3 es un grupo (C2-C4)-alquilo y la configuración de C en el sustituyente (R2O)(R3COO)CH es R ó S, los cuales han mostrado ser activos frente a varias líneas celulares cancerosas humanas, en particular, frente a líneas celulares de melanoma, leucemia, cáncer de pulmón de células no pequeñas, cáncer renal, de ovarios, de colon, del SNC, de mama y de próstata. Esto significa que estos compuestos son agentes anticancerosos prometedores para tratar varios tipos de cáncer.
(FR)L'invention concerne des composés représentés par la formule (15), illustrés ci-après. Dans ladite formule, R1 désigne H ou I, R2 désigne un radical sélectionné parmi alkyle (C1-C16), phényle et benzyle, R3 désigne un groupe alkyle (C2-C4) et la configuration de C dans le substituant (R2O)(R3COO)CH est R ou S, lesquels se sont révélés être actifs face à diverses lignées cellulaires cancéreuses, humaines, en particulier, face aux lignées cellulaires du mélanome, de la leucémie, du cancer du poumon non à petites cellules, du cancer du rein, des ovaires, du côlon, du SNC, du sein et de la prostate, ce qui signifie que lesdits composés sont des agents anticancéreux prometteurs pour traiter divers types de cancers.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Spanish (ES)
Filing Language: Spanish (ES)