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1. (WO2009056490) NEW ANTIBODIES SPECIFIC OF THE β-AMYLOID PEPTIDES AND THEIR USES AS DIAGNOSTIC AGENTS OR DRUGS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/056490    International Application No.:    PCT/EP2008/064432
Publication Date: 07.05.2009 International Filing Date: 24.10.2008
Chapter 2 Demand Filed:    24.08.2009    
IPC:
C07K 16/18 (2006.01), A61K 39/395 (2006.01), G01N 33/577 (2006.01), C12N 5/18 (2006.01), C07K 14/47 (2006.01), A61P 25/28 (2006.01)
Applicants: INNOGENETICS NV [BE/BE]; Industriepark Zwijnaarde 7 Box 4 B-9052 GENT-ZWIJNAARDE (BE) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BG, BH, BY, BZ, CA, CH, CN, CU, CY, CZ, DE, DK, DM, EE, ES, FI, FR, GB, GD, GE, GR, HR, HU, IE, IN, IS, IT, JP, KG, KM, KN, KP, KZ, LA, LC, LK, LT, LU, LV, LY, MC, MD, MG, MK, MN, MT, NL, OM, PG, PL, PT, RO, RS, RU, SC, SE, SI, SK, SM, ST, TJ, TM, TR, TT, UZ, VC only).
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) [FR/FR]; 101, rue de Tolbiac F-75654 PARIS CEDEX 13 (FR) (For All Designated States Except US).
SANOFI-AVENTIS [FR/FR]; 174, Avenue de France F-75013 PARIS (FR) (For All Designated States Except US).
VANMECHELEN, Eugeen [BE/BE]; (BE) (For US Only).
GROGNET, Pierre [BE/BE]; (BE) (For US Only).
SERGEANT, Nicolas [FR/FR]; (FR) (For US Only).
GOMPEL, Marie [FR/FR]; (FR) (For US Only).
DELACOURTE, André [FR/FR]; (FR) (For US Only).
BUEE, Luc [FR/FR]; (FR) (For US Only).
PRADIER, Laurent [FR/FR]; (FR) (For US Only).
BLANCHARD-BREGEON, Véronique [FR/FR]; (FR) (For US Only)
Inventors: VANMECHELEN, Eugeen; (BE).
GROGNET, Pierre; (BE).
SERGEANT, Nicolas; (FR).
GOMPEL, Marie; (FR).
DELACOURTE, André; (FR).
BUEE, Luc; (FR).
PRADIER, Laurent; (FR).
BLANCHARD-BREGEON, Véronique; (FR)
Agent: GROSSET-FOURNIER, Chantal; 54, rue Saint-Lazare F-75009 PARIS (FR)
Priority Data:
07119537.4 29.10.2007 EP
Title (EN) NEW ANTIBODIES SPECIFIC OF THE β-AMYLOID PEPTIDES AND THEIR USES AS DIAGNOSTIC AGENTS OR DRUGS
(FR) NOUVEAUX ANTICORPS SPÉCIFIQUES DES PEPTIDES Β-AMYLOÏDES ET LEURS UTILISATIONS COMME AGENTS DE DIAGNOSTIC OU COMME MÉDICAMENTS
Abstract: front page image
(EN)The present invention relates to a monoclonal antibody which specifically binds to the N-terminal region of Aβ8-X peptide, x being comprised from 11 to 42, and recognises neither Aβ1-40 nor Aβ1-42 and which presents a high affinity with respect to Aβ8-X peptide, such as determined by an immunological complex formation between the monoclonal antibody and the peptide Aβ8-X.
(FR)La présente invention concerne un anticorps monoclonal qui se lie spécifiquement à la région N-terminale du peptide Aβ8-X, x étant compris entre 11 et 42, qui ne reconnaît ni Aβ1-40 ni Aβ1-42 et qui présente pour le peptide Aβ8-X une affinité élevée telle que déterminée par la formation d'un complexe immunologique entre l'anticorps monoclonal et le peptide Aβ8-X.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)