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1. (WO2009056029) PURIFICATION METHOD OF PEMETREXED SALTS,SODIUM SALTS AND DISODIUM SALTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/056029    International Application No.:    PCT/CN2008/072758
Publication Date: 07.05.2009 International Filing Date: 21.10.2008
IPC:
C07D 487/04 (2006.01), A61K 31/519 (2006.01), A61P 35/00 (2006.01)
Applicants: CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD. [CN/CN]; No.565 Tushan Rd., Nan'an District Chongqing 400061 (CN) (For All Designated States Except US).
LUO, Jie [CN/CN]; (CN) (For US Only).
LIN, Meng [CN/CN]; (CN) (For US Only).
LIN, Bo [CN/CN]; (CN) (For US Only).
YE, Wenrun [CN/CN]; (CN) (For US Only).
QIN, Yongmei [CN/CN]; (CN) (For US Only).
DENG, Jie [CN/CN]; (CN) (For US Only)
Inventors: LUO, Jie; (CN).
LIN, Meng; (CN).
LIN, Bo; (CN).
YE, Wenrun; (CN).
QIN, Yongmei; (CN).
DENG, Jie; (CN)
Agent: UNITALEN ATTORNEYS AT LAW; 7th Floor, Scitech Place No.22, Jian Guo Men Wai Ave., Chao Yang District Beijing 100004 (CN)
Priority Data:
200710092879.7 24.10.2007 CN
Title (EN) PURIFICATION METHOD OF PEMETREXED SALTS,SODIUM SALTS AND DISODIUM SALTS
(FR) PROCÉDÉ DE PURIFICATION DE SELS, SELS SODIQUES ET SELS DISSODIQUES DE PEMETREXED
(ZH) 培美曲塞盐、培美曲塞钠盐、培美曲塞二钠的纯化方法
Abstract: front page image
(EN)A purification method of pemetrexed salts by means of salting-out. The pemetrexed salts are defined as formula (III) in which, (1) If M3+ is H+, then M1+ and M2+ are H+, Li+, Na+ or K+ independently. M1+ and M2+ are the same or not ,but they can not be H+ simultaneously; (2)If M3+ is Li+, Na+ or K+, then M1+ and M2+ are Li+, Na+ or K+ independently. M1+, M2+ and M3+ are the same or not.
(FR)L'invention porte sur un procédé de purification de sels de pemetrexed au moyen d'un relargage. Les sels de pemetrexed sont définis comme étant représentés par la formule (III) dans laquelle, (1) si M3+ représente H+, alors M1+ et M2+ représentent H+, Li+, Na+ ou K+ indépendamment ; M1+ et M2+ sont identiques ou différents, mais ils ne peuvent pas représenter H+ simultanément ; (2) si M3+ représente Li+, Na+ ou K+, alors M1+ et M2+ représentent indépendamment Li+, Na+ ou K+ ; M1+, M2+ et M3+ sont identiques ou différents.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)