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1. (WO2009055937) ALTERED N-CADHERIN PROCESSING IN TUMOR CELLS BY FURLN AND PROPROTELN CONVERTASE 5A (PC5A)
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/055937    International Application No.:    PCT/CA2008/001949
Publication Date: 07.05.2009 International Filing Date: 03.11.2008
IPC:
A61K 38/43 (2006.01), A61K 31/7105 (2006.01), A61K 49/00 (2006.01), A61P 35/00 (2006.01), G01N 33/53 (2006.01)
Applicants: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY [CA/CA]; 1555 Peel Street, 11th Floor, Montréal, Québec H3A 3L8 (CA) (For All Designated States Except US).
IRCM (INSTITUT DE RECHERCHES CLINIQUES DE MONTREAL) [CA/CA]; 110 Pine Ave. West, Montréal, Québec H2W 1R7 (CA) (For All Designated States Except US).
MOUNT SINAI SCHOOL OF MEDICINE [US/US]; Office of Technology & Business Development, One Gustave L. Levy Place, Box 1675, New York, New York 10029-6574 (US) (For All Designated States Except US).
MARET, Deborah [CA/CA]; (CA) (For US Only).
COLMAN, David, R. [US/CA]; (CA) (For US Only).
GRUZGLIN, Eugenia [US/US]; (US) (For US Only).
SEIDAH, Nabil [CA/CA]; (CA) (For US Only)
Inventors: MARET, Deborah; (CA).
COLMAN, David, R.; (CA).
GRUZGLIN, Eugenia; (US).
SEIDAH, Nabil; (CA)
Agent: OGILVY RENAULT LLP; Bureau 2500, 1, Place Ville Marie, Montréal, Québec H3B 1R1 (CA)
Priority Data:
60/996,119 01.11.2007 US
Title (EN) ALTERED N-CADHERIN PROCESSING IN TUMOR CELLS BY FURLN AND PROPROTELN CONVERTASE 5A (PC5A)
(FR) TRAITEMENT DE LA CADHÉRINE MODIFIÉE DANS DES CELLULES TUMORALES
Abstract: front page image
(EN)The present invention relates to a method for diagnosis and/or prognosis of cancer and for monitoring the progression of cancer and/or the therapeutic efficacy of an anti-cancer treatment in a subject by determining the molecular form of cadherin at the cell surface of cancer cells in the subject. The invention also relates to a method for preventing, inhibiting or treating cancer or its metastasis in a subject by increasing the adhesive forms of cadherin and/or decreasing the non-adhesive forms of cadherin at the cell surface. The invention also relates to a method step of determining the expression level of furin and proprotein convertase 5A (PC5A).
(FR)La présente invention concerne un procédé de diagnostic et/ou de pronostic du cancer, et de surveillance de la progression du cancer et/ou de l'efficacité thérapeutique d'un traitement anti-cancéreux chez un sujet. Ledit procédé consiste à déterminer la forme moléculaire de la cadhérine sur la surface cellulaire des cellules cancéreuses dudit sujet. L'invention concerne également un procédé de prévention, d'inhibition ou de traitement du cancer ou de ses métastases chez un sujet, par l'augmentation des formes adhésives de la cadhérine et/ou la diminution des formes non adhésives de la cadhérine sur la surface cellulaire.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)