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1. (WO2009055854) CHIMERIC RELAXIN POLYPEPTIDES COMPRISING AN A AND B CHAIN DERIVED FROM DIFFERENT RELAXIN FAMILY PEPTIDES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/055854    International Application No.:    PCT/AU2008/001605
Publication Date: 07.05.2009 International Filing Date: 30.10.2008
Chapter 2 Demand Filed:    26.08.2009    
IPC:
C07K 14/64 (2006.01), A61P 9/00 (2006.01), C07K 19/00 (2006.01), A61K 31/13 (2006.01), A61P 25/00 (2006.01), C12N 15/16 (2006.01), A61K 38/22 (2006.01), C07K 14/575 (2006.01), C12N 15/17 (2006.01), A61K 38/28 (2006.01), C07K 14/62 (2006.01), C12N 15/18 (2006.01), A61K 38/30 (2006.01), C07K 14/65 (2006.01)
Applicants: HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE [AU/AU]; The University of Melbourne Parkville, Victoria 3010 (AU) (For All Designated States Except US).
BATHGATE, Ross, Alexander, David, [AU/AU]; (AU) (For US Only).
HOSSAIN, Mohammed, Akhter [AU/AU]; (AU) (For US Only).
SAMUEL, Chrishan, Surendran [AU/AU]; (AU) (For US Only).
WADE, John, Desmond [AU/AU]; (AU) (For US Only).
TREGEAR, Geoffrey, W [AU/AU]; (AU) (For US Only)
Inventors: BATHGATE, Ross, Alexander, David,; (AU).
HOSSAIN, Mohammed, Akhter; (AU).
SAMUEL, Chrishan, Surendran; (AU).
WADE, John, Desmond; (AU).
TREGEAR, Geoffrey, W; (AU)
Agent: RECCHIA, Gavin, Dean; Davies Collison Cave Level 14 255 Elizabeth Street Sydney, New South Wales 2000 (AU)
Priority Data:
60/983,768 30.10.2007 US
Title (EN) CHIMERIC RELAXIN POLYPEPTIDES COMPRISING AN A AND B CHAIN DERIVED FROM DIFFERENT RELAXIN FAMILY PEPTIDES
(FR) POLYPEPTIDES CHIMÉRIQUES DE LA RELAXINE COMPRENANT UNE CHAÎNE A ET UNE CHAÎNE B ISSUES DE DIFFÉRENTS PEPTIDES DE LA FAMILLE DE LA RELAXINE
Abstract: front page image
(EN)Modified relaxin polypeptides are disclosed wherein the B chain comprises the core sequence CGRxxxRxxI/VxxCG (SEQ ID NO: 1), specifically KLCGRELVRAQIAIC. Chimeric polypeptides comprising a B chain with the core sequence CGRxxxRxxFVxxCG (SEQ ID NO: 1) and an A chain from a heterologous relaxin family peptide are also disclosed. Specifically, chimeric polypeptides comprising a B chain from relaxin-2, and an A chain from relaxin- 1, relaxin-3, insulin, IGF-I, IGF-II, INSL3, INSL4, INSL5 or INSL6, are disclosed.
(FR)L'invention porte sur des polypeptides modifiés de la relaxine, dans lesquels la chaîne B comprend la séquence cœur CGRxxxRxxI/VxxCG (SEQ ID NO: 1), spécifiquement KLCGRELVRAQIAIC. L'invention porte également sur des polypeptides chimériques comprenant une chaîne B comportant la séquence cœur CGRxxxRxxFVxxCG (SEQ ID NO: 1) et une chaîne A provenant d'un peptide hétérologue de la famille de la relaxine. De façon spécifique, l'invention porte sur des polypeptides chimériques comprenant une chaîne B provenant de la relaxine-2 et une chaîne A provenant de la relaxine-1, de la relaxine-3, de l'insuline, d'IGF-I, d'IGF-II, d'INSL3, d'INSL4, d'INSL5 ou d'INSL6.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)