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1. WO2009053716 - PURINE DERIVATIVES USEFUL AS PI3 KINASE INHIBITORS

Publication Number WO/2009/053716
Publication Date 30.04.2009
International Application No. PCT/GB2008/003622
International Filing Date 27.10.2008
IPC
C07D 471/10 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
10Spiro-condensed systems
C07D 473/34 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
473Heterocyclic compounds containing purine ring systems
26with an oxygen, sulfur, or nitrogen atom directly attached in position 2 or 6, but not in both
32Nitrogen atom
34attached in position 6, e.g. adenine
C07D 498/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
498Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 498/08 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
498Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
08Bridged systems
C07D 498/10 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
498Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
10Spiro-condensed systems
C07D 519/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/ or C07D455/257
CPC
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 3/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
A61P 3/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
Applicants
  • F.HOFFMANN-LA ROCHE AG [CH]/[CH] (AllExceptUS)
  • GOLDSMITH, Paul [GB]/[GB] (UsOnly)
  • HANCOX, Timothy, Colin [GB]/[GB] (UsOnly)
  • HUDSON, Alan [GB]/[GB] (UsOnly)
  • PEGG, Neil, Anthony [GB]/[GB] (UsOnly)
  • KULAGOWSKI, Janusz, Josef [GB]/[GB] (UsOnly)
  • NADIN, Alan, John [GB]/[GB] (UsOnly)
  • PRICE, Stephen [GB]/[GB] (UsOnly)
Inventors
  • GOLDSMITH, Paul
  • HANCOX, Timothy, Colin
  • HUDSON, Alan
  • PEGG, Neil, Anthony
  • KULAGOWSKI, Janusz, Josef
  • NADIN, Alan, John
  • PRICE, Stephen
Agents
  • KEEN, Celia, Mary
Priority Data
0721105.526.10.2007GB
0805300.120.03.2008GB
0807502.024.04.2008GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PURINE DERIVATIVES USEFUL AS PI3 KINASE INHIBITORS
(FR) DÉRIVÉS DE PURINE UTILES COMME INHIBITEURS DE PI3 KINASE
Abstract
(EN) This invention provides a compound which is a purine of formula (Ia) or (Ib): and the pharmaceutically acceptable salts thereof that are inhibitors of PI3K and a selective for the p110δ isoform, which is a class Ia PI3 kinase, over other class Ia PI3 kinases and over class Ib kinases. The compounds may be used to treat diseases and disorders arisi from abnormal cell growth, function or behaviour associated with PI3 kinase such as cance immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders.
(FR) L'invention porte sur un composé qui est une purine de formule (Ia) ou (Ib) : et sur les sels pharmaceutiquement acceptables de celui-ci qui sont des inhibiteurs de PI3K et sélectifs pour l'isoforme p110δ, qui est une PI3 kinase de classe Ia, par rapport à une autre PI3 kinase de classe Ia et par rapport aux kinases de classe Ib. Les composés peuvent être utilisés pour traiter des maladies et des troubles provenant d'une croissance, d'une fonction ou d'un comportement cellulaires anormaux associés à la PI3 kinase tels que le cancer, des troubles immunitaires, une maladie cardiovasculaire, une infection virale, une inflammation, des troubles du métabolisme/de la fonction endocrinienne et des troubles neurologiques.
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