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1. WO2009053629 - TREATMENT OF TUMOURS USING T LYMPHOCYTE PREPARATIONS

Publication Number WO/2009/053629
Publication Date 30.04.2009
International Application No. PCT/FR2008/051842
International Filing Date 10.10.2008
IPC
A61K 35/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C12N 5/0783 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
078Cells from blood or from the immune system
0783T cells; NK cells; Progenitors of T or NK cells
CPC
A61K 2035/124
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
124the cells being hematopoietic, bone marrow derived or blood cells
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C12N 2510/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2510Genetically modified cells
C12N 5/0087
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor;
0081Purging biological preparations of unwanted cells
0087Purging against subsets of blood cells, e.g. purging alloreactive T cells
C12N 5/0636
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor;
06Animal cells or tissues; Human cells or tissues
0602Vertebrate cells
0634Cells from the blood or the immune system
0636T lymphocytes
Applicants
  • UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) [FR]/[FR] (AllExceptUS)
  • ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS [FR]/[FR] (AllExceptUS)
  • CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE [FR]/[FR] (AllExceptUS)
  • UNIVERSITE PARIS XII [FR]/[FR] (AllExceptUS)
  • COHEN, José [FR]/[FR] (UsOnly)
  • KLATZMANN, David [FR]/[FR] (UsOnly)
  • MAURY, Sébastien [FR]/[FR] (UsOnly)
  • LEMOINE, François [FR]/[FR] (UsOnly)
Inventors
  • COHEN, José
  • KLATZMANN, David
  • MAURY, Sébastien
  • LEMOINE, François
Agents
  • CHAJMOWICZ, Marion
  • BECKER, Philippe
  • GALLOIS, Valérie
  • TEZIER HERMAN, Béatrice
Priority Data
60/960,76212.10.2007US
Publication Language French (FR)
Filing Language French (FR)
Designated States
Title
(EN) TREATMENT OF TUMOURS USING T LYMPHOCYTE PREPARATIONS
(FR) TRAITEMENT DE TUMEURS PAR DES PREPARATIONS DE LYMPHOCYTES T
Abstract
(EN)
The invention relates to the treatment of a tumour in a patient, by injecting T lymphocytes depleted of regulatory T lymphocytes, and expressing a molecule enabling the specific destruction thereof, wherein the patient receives, beforehand, a non-myeloablative or myeloablative lymphopenia-inducing treatment.
(FR)
L'invention concerne le traitement d'une tumeur chez un patient, par injection de lymphocytes T déplétés en lymphocytes T régulateurs, et exprimant une molécule permettant leur destruction spécifique, le patient recevant au préalable un traitement lymphopéniant non myéloablatif ou myéloablatif.
Also published as
Latest bibliographic data on file with the International Bureau